Predictive factors for surgical treatment in preterm neonates with necrotizing enterocolitis: a multicenter case-control
- PDF / 317,728 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 88 Downloads / 159 Views
ORIGINAL ARTICLE
Predictive factors for surgical treatment in preterm neonates with necrotizing enterocolitis: a multicenter case-control study Sofia el Manouni el Hassani 1,2 & Hendrik J. Niemarkt 3 & Joep P. M. Derikx 4 & Daniel J. C. Berkhout 1,2 & Andrea E. Ballón 2 & Margot de Graaf 2 & Willem P. de Boode 5 & Veerle Cossey 6 & Christian V. Hulzebos 7 & Anton H. van Kaam 8,9 & Boris W. Kramer 10 & Richard A. van Lingen 11 & Daniel C. Vijlbrief 12 & Mirjam M. van Weissenbruch 8 & Marc A. Benninga 1 & Nanne K. H. de Boer 13 & Tim G. J. de Meij 2 Received: 7 April 2020 / Revised: 17 November 2020 / Accepted: 23 November 2020 # The Author(s) 2020
Abstract Necrotizing enterocolitis (NEC) is one of the most common and lethal gastrointestinal diseases in preterm infants. Early recognition of infants in need for surgical intervention might enable early intervention. In this multicenter case-control study, performed in nine neonatal intensive care units, preterm born infants (< 30 weeks of gestation) diagnosed with NEC (stage ≥ IIA) between October 2014 and August 2017 were divided into two groups: (1) medical (conservative treatment) and (2) surgical NEC (sNEC). Perinatal, clinical, and laboratory parameters were collected daily up to clinical onset of NEC. Univariate and multivariate logistic regression analyses were applied to identify potential predictors for sNEC. In total, 73 preterm infants with NEC (41 surgical and 32 medical NEC) were included. A low gestational age (p value, adjusted odds ratio [95%CI]; 0.001, 0.91 [0.86– 0.96]), no maternal corticosteroid administration (0.025, 0.19 [0.04–0.82]), early onset of NEC (0.003, 0.85 [0.77–0.95]), low serum bicarbonate (0.009, 0.85 [0.76–0.96]), and a hemodynamically significant patent ductus arteriosus for which ibuprofen was administered (0.003, 7.60 [2.03–28.47]) were identified as independent risk factors for sNEC. Conclusions: Our findings may support the clinician to identify infants with increased risk for sNEC, which may facilitate early decisive management and consequently could result in improved prognosis.
Communicated by Piet Leroy * Sofia el Manouni el Hassani [email protected]
Anton H. van Kaam [email protected]
Hendrik J. Niemarkt [email protected]
Boris W. Kramer [email protected]
Joep P. M. Derikx [email protected]
Richard A. van Lingen [email protected]
Daniel J. C. Berkhout [email protected]
Daniel C. Vijlbrief [email protected]
Andrea E. Ballón [email protected]
Mirjam M. van Weissenbruch [email protected]
Margot de Graaf [email protected]
Marc A. Benninga [email protected]
Willem P. de Boode [email protected] Veerle Cossey [email protected] Christian V. Hulzebos [email protected]
Nanne K. H. de Boer [email protected] Tim G. J. de Meij [email protected] Extended author information available on the last page of the article
Eur J Pediatr
What is Known: • In 27–52% of th
Data Loading...
