Prevention of Intra-abdominal Adhesions by Electrical Stimulation
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INNOVATIVE SURGICAL TECHNIQUES AROUND THE WORLD
Prevention of Intra-abdominal Adhesions by Electrical Stimulation Ildar R. Fakhradiyev1 • Almabayev Ydyrys1 • Saliev Timur1 • Almabayeva Aygul2 • Tanabayev Baimakhan3 • Yergazina Maral1 • Serikpayev Zhandos1 • Loreto B. Feril Jr.4
Ó Socie´te´ Internationale de Chirurgie 2020
Abstract The study investigated the ability of transdermal electric stimulation to prevent the formation of intraabdominal adhesions in the combination with SeprafilmÒ (anti-adhesive agent). One hundred and twenty-eight (128) rabbits were subjected to a surgical procedure to simulate the adhesion processes. After the simulation, the animals were divided into 4 groups (32 animals each), depending on the application of the methods of prevention: (1) control group (no anti-adhesives or electro-stimulation) (CG); (2) comparison group (applications of SeprafilmÒ) (SF); (3) comparison group 2 (transdermal electric stimulation of the abdominal muscles) TES; (4) group (transdermal electric stimulation ? SeprafilmÒ) (TES ? SF). We observed that the application of the SeprafilmÒ alone led to a significant decrease in the adhesive process compared to the control group (CG) (p \ 0.01). The adhesion process in the group underwent transdermal electrical stimulation (TES) was significantly lower compared to the SeprafilmÒ group (SF) (p B 0.05). The results demonstrated a significant decrease in the adhesion processes in the SF ? TES group on days 1, 3, 7 and 14 in comparison with the CG group (p = 0.001), SF group (p = 0.001) and TES group (p = 0.01) group of animals. This study showed the efficacy of transdermal electrical muscle stimulation for the prevention of intraabdominal adhesions. Moreover, the combination of SeprafilmÒ anti-adhesion agent and electrical muscle stimulation resulted in the complete absence of adhesions. Our findings indicate the potential of such strategy for further clinical application.
Introduction
& Ildar R. Fakhradiyev [email protected] 1
Laboratory of Experimental Medicine, S.D. Asfendiyarov Kazakh National Medical University, 94, Tole-bi Str., Almaty 050000, Republic of Kazakhstan
2
Astana Medical University, 49a Beibitshilik St., Nur-Sultan 010000, Republic of Kazakhstan
3
South-Kazakhstan Medical Academy, 1/1 Al-Farabi Square, Shymkent 160019, Republic of Kazakhstan
4
Department of Anatomy, Fukuoka University School of Medicine, Nanakuma Jonan-ku, Fukuoka, Japan
Adhesion is a serious problem in abdominal surgery. Adhesion processes begin in up to 90% of abdominal operations and 10–30% develops adhesions [1]. Progress in surgical interventions has significantly reduced the rates of adhesion, but there is still a need for better prevention. Proper surgical technique is an important factor in preventing adhesions. Minimizing the exposure of tissues (laparoscopic technique), preventing intestinal drying, avoiding introduction of foreign bodies such as talcum powder, minimizing the use of suture materials and debridement are ways to reduce the risk of this patholog
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