Prognostic impacts of the combined positive score and the tumor proportion score for programmed death ligand-1 expressio
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ORIGINAL ARTICLE
Prognostic impacts of the combined positive score and the tumor proportion score for programmed death ligand‑1 expression by double immunohistochemical staining in patients with advanced gastric cancer Kohei Yamashita1 · Masaaki Iwatsuki1,2 · Kazuto Harada1,2 · Kojiro Eto1 · Yukiharu Hiyoshi1 · Takatsugu Ishimoto1 · Yohei Nagai1 · Shiro Iwagami1 · Yuji Miyamoto1 · Naoya Yoshida1 · Yoshihiro Komohara3 · Jaffer A. Ajani2 · Hideo Baba1 Received: 19 June 2019 / Accepted: 17 August 2019 © The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2019
Abstract Background The tumor proportion score (TPS) and combined positive score (CPS) have been developed to assess programmed death ligand 1 (PD-L1) expression in gastric cancer (GC). This study aimed to elucidate the role of TPS and CPS as prognostic biomarkers. Methods A total of 191 patients with GC who received curative gastrectomy were retrospectively enrolled. Double immunohistochemistry of PD-L1 and ionized calcium binding adaptor molecule 1 was performed to clearly distinguish PD-L1 expression between tumor cells and macrophages. Survival analysis for PD-L1 expression by TPS and CPS was performed. Results PD-L1 positivity was detected in 39 patients (20.4%) by TPS and in 137 patients (71.7%) by CPS. Patients with PD-L1 positivity by CPS experienced significantly shorter overall survival (OS) (P
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