Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer
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Journal of Pharmaceutical Investigation https://doi.org/10.1007/s40005-020-00495-8
ORIGINAL ARTICLE
Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer Iftikhar Khan1 · Sakib Yousaf2 · Mohammad Najlah3 · Waqar Ahmed4 · Abdelbary Elhissi5 Received: 29 May 2020 / Accepted: 28 July 2020 © The Author(s) 2020
Abstract Purpose The aim of this study was to develop and compare proliposome powder and proliposome tablet formulations for drug delivery from a Pari-LC Sprint nebulizer. Methods Proliposome powders were prepared by the slurry method and sorbitol or mannitol carbohydrate carrier were used in a 1:10 and 1:15 w/w lipid phase to carrier ratio. Beclometasone dipropionate (BDP; 2 mol%) was incorporated in the lipid phase. Proliposome powders were compressed into tablets, and liposomes were generated from proliposome powders or tablets within the nebulizer reservoir for subsequent aerosolization. Results Comparatively, shorter sputtering times were reported for the tablet formulations (≈
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