Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary In
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C
hinese Journal of Integrative Medicine
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Available online at link.springer.com/journal/11655 Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: [email protected]
Original Article
Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial OU Yang1, SUN Sheng-jia1, SHI Hai-ming1, LUO Jian-feng2, LUO Xin-ping1, SHEN Yun-zhi1, CHEN Yu-fei1, FAN Wei-hu1, LIU Hong-ying3, and SHEN Wei1 Objective: To evaluate the protective effects of salvianolate on percutaneous coronary intervention ABSTRACT Objective: (PCI) related myocardial injury or myocardial infarction after elective PCI in non-ST-segment elevation acute Methods:: A total of 149 patients with NSTE-ACS who underwent coronary syndrome (NSTE-ACS) patients. Methods elective PCI were enrolled. The patients were randomly allocated in a 1:1 ratio to the salvianolate group (74 cases) or the control group (75 cases). After exclusion criteria of coronary angiography, 60 patients with PCI therapy remained in the salvianolate group and 68 in the control group. The incidence and the severity of PCI related myocardial injury or myocardial infarction, in addition to major adverse cardiac events (MACEs) during 1 year follow-up after PCI were studied between the two groups. Multivariate logistic regression analysis was used to determine the independent factors for PCI related myocardial injury or myocardial infarction after Results:: Compared with the control group, salvianolate treatment reduced the incidence of PCI elective PCI. Results related severe myocardial injury or myocardial infarction (11.7% vs . 26.5%, P =0.035). The rate of MACEs or all-cause death within 1 month or 1 year after the procedure was not significantly different between the two Conclusions:: Periprocedural treatment with salvianolate reduces the incidence of PCI related severe groups. Conclusions myocardial injury or myocardial infarction, although it does not influence clinical prognosis. [Chinese clinical trial registry: ChiCTR1800016992] KEYWORDS myocardial infarction, acute coronary syndrome, percutaneous coronary intervention, salvianolate
In recent years, percutaneous coronary intervention (PCI) has increased rapidly and has played an important role in reducing coronary stenosis and alleviating ischemic symptoms. However, PCI related myocardial injury or myocardial infarction (MI) occurs approximately 20%–40% in stable coronary artery disease (CAD) and 40%–50% in MI patients who received elective PCI. (1) Zeitouni, et al (2) has reported that PCI related MI could negatively impact on clinical prognosis. Patients with periprocedural MI and myocardial injury had a higher rate of cardiovascular events at 30 days and 1 year after PCI.(2) Yet, there have been no proven effective therapies to reduce periprocedural MI or injury safely and economically. It is challenging but also has significant benefit to find any therapy to alleviate PCI related MI or my
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