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Deep vein thrombosis, seizures and miscarriage: 3 case reports In a retrospective study, which was carried out to evaluate adverse events following immunisation (AEFI) with quadrivalent human papillomavirus vaccine during March 2014–December 2016 (reported at Sao Paulo state, Brazil), three women [ages not stated] were described, of whom one woman developed upper-extremity deep vein thrombosis; another woman, who had a history of epilepsy, developed seizures with cerebral oedema; and third woman had miscarriage after receiving quadrivalent human papillomavirus vaccine [routes, dosages and times to reactions onset not stated]. All women were hospitalised due to occurrence the AEFI. The adverse events resolved completely within a week of occurrence, without sequelae. Author comment: "[A]mong the severe AEFI, we identified cases of Guillain-Barr´ e Syndrome (GBS), upper-extremity deep vein thrombosis, seizures and a miscarriage temporally associated with the HPV vaccine..." Mauro AB, et al. Adverse events following Quadrivalent HPV vaccination reported in Sao Paulo State, Brazil, in the first three years after introducing the vaccine for routine immunization (March 2014 to December 2016). Revista do Instituto de Medicina Tropical de Sao Paulo 61: Jan 2019. Available from: URL: http:// 803443415 doi.org/10.1590/s1678-9946201961043 - Brazil

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Reactions 4 Jan 2020 No. 1785