Quantitative blush evaluator (QuBE) accurately quantifies microvascular dysfunction in patients with ST-Elevation Myocar
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ORAL PRESENTATION
Open Access
Quantitative blush evaluator (QuBE) accurately quantifies microvascular dysfunction in patients with ST-Elevation Myocardial Infarction; comparison with Cardiovascular Magnetic Resonance Christian Hamilton-Craig1*, Italo Porto2, Giovanni Luigi De Maria2, Luigi Natale2, Filippo Crea2 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Introduction
traced, and hemorrage identified as the dark band within bright signal on T2
Background
After ST-elevation myocardial infarction (STEMI), microvascular obstruction (MVO) can be assessed using angiographic myocardial ‘blush’ grade (MBG), subject to interoperator variability. Quantitative blush evaluator (QuBE) is a free computer-calculated algorithm, with improved reproducibility. We aimed to compare QuBE in detecting MVO and its severity in comparison to the gold standard, cardiovascular magnetic resonance (CMR).
Methods Fifty-two STEMI treated with successful primary-PCI were enrolled. QuBE values were blindly calculated on post-procedure angiogram and patients divided in tertiles (ter) according to QuBE values. All patients underwent CMR (GE 1.5T) 4-7 days after STEMI, for quantitative assessment of infarct size (IS), area-at-risk (AAR), myocardial salvage index (MSI), MVO (both as first pass MVO (FP-MVO) and delayed-enhancement MVO (DE-MVO)), and presence of intramyocardial hemorrhage on T2-weighted sequences. Indices were measured blindly by two expert readers with SMCR level 3, using ReportCard (v4.0) software. LGE infarct size was quantified using threshold >5SD, T2 sequence >2SD as previously described. MVO was manually
1 University of Queensland, Brisbane, Australia Full list of author information is available at the end of the article
Results QuBE values were inversely related to IS, both as percentage (R: -0.4; p:0.001) and as mass (R:-0.4; p: 0.008), to DE-MVO, both as percentage (R: -0.7; p
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