Quantitative T1-maps delineate myocardium at risk as accurately as T2-maps - experimental validation with microspheres
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Quantitative T1-maps delineate myocardium at risk as accurately as T2-maps - experimental validation with microspheres Martin Ugander1*, Paul S Bagi1, Abiola J Oki1, Billy Chen1, Li-Yueh Hsu1, Anthony H Aletras1, Saurabh Shah2, Andreas Greiser3, Peter Kellman1, Andrew E Arai1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Introduction Clinical quantitative T1 and T2 mapping sequences are available, but it is unclear which, if either, is more accurate for determining myocardium at risk. Purpose To validate and determine the accuracy for using in vivo T1 mapping or T2 mapping for determining myocardium at risk, compared to blood flow quantification at coronary occlusion by microspheres. Methods Dogs (n=12) underwent coronary occlusion (2 hours), during which microspheres were injected into the left atrium, followed by reperfusion (4 hours). The entire left ventricle was imaged at 1.5T (Siemens) in contiguous short-axis slices with a Modified Look-Locker Inversion-recovery sequence for T1 mapping (Messroghli, JMRI, 2007), and a T2-prepared SSFP sequence for T2 mapping (Giri, JCMR, 2009). Myocardium at risk was defined as regions in the left ventricle which had a T1 or T2 value greater than 2SD from remote. In four dogs, hearts were excised and blood flow (ml/min/g) was determined by microsphere analysis in 16 sectors per short-axis slice for all short-axis slices in the left ventricle. Myocardium at risk was defined as regions in the left ventricle with a blood flow at occlusion less than 2SD from remote.
Results Global myocardium at risk, expressed as percent of left ventricular mass (%LVM), showed similar results for T1 mapping compared to T2 mapping (n=12, mean+/SD difference 1.5+/-4.0 %LVM, R2=0.86, p
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