Quercetin and cervical cancer: a view of great scope
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Medicinal Chemistry Research https://doi.org/10.1007/s00044-020-02622-4
REVIEW ARTICLE
Quercetin and cervical cancer: a view of great scope Abolfazl Mehdizadehkashi1 Fatemeh Sadoughi2 Mansooreh Samimi1 ●
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Received: 29 June 2020 / Accepted: 26 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Cervical cancer (CC) is the most common gynecological cancer and is one of the results of high-risk HPV infection. Recent statistics demonstrate that 90% of cervical cancer cases are diagnosed in low- and middle-income countries. These results are observed due to the poor sanitation and lack of proper preventive strategies. Quercetin is a plant compound with a great number of beneficial properties which increasing the level of sanitation or acting as a preventive agent are not of its capabilities; however, what quercetin is capable of is preventing the cancer from progression in CC patients. Cell proliferation, growth, viability, survival, and migration are just a limited number of cellular processes which are prone to be affected by quercetin. In this review, we have considered each distinct role of quercetin on cellular and molecular processes, occurring as a consequence of becoming cancerous, in the cells of uterine cervix. We look forward to attract the attention of scientific community to this marvelous agent in order to help CC patients from taking expensive, toxic, and risky common therapeutic methods used for treating early to metastatic cervical cancer. Keywords Cervical cancer Inflammation Apoptosis Quercetin ●
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Abbreviations CC Cervical cancer ERK Extracellular signal-related kinases JNK Jun amino-terminal kinases
Introduction Cancer is one of the most lethal and complicated diseases which can occur in almost every cell, tissue, organ, and system of the human body (Evan and Vousden 2001). Cervical cancer (CC) is a condition which involves the uterine cervix in the reproductive system of women and is the results of a number of genetic and epigenetic alterations caused by high-risk HPV infection (Fang et al. 2014). Notwithstanding the fact that only half of the global population is prone to be affected by this disease, still, CC occupies the fourth position between the most common
* Mansooreh Samimi [email protected] 1
Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
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Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
cancers of both sexes. Furthermore, CC has the most number of new diagnosed cases among the gynecological cancers. All these suggest that a great number of health, social, and economic disadvantages have gotten the women of every corner of the world in a lot of trouble. Thus, providing more therapeutic options as well as diagnostic methods for patients of this cancer has been highlighted in recent investigations. The family of flavonoids is known as the secondary metabolites produced in plants and fungi and en
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