Relative hepatic weight using body weight may be not accurate
- PDF / 161,393 Bytes
- 2 Pages / 595.22 x 842 pts (A4) Page_size
- 51 Downloads / 227 Views
Correspondence Relative hepatic weight using body weight may be not accurate
W
Correspondence
e read the paper entitled "A high-fat highenergy diet influences hepatic CYP3A expression and activity in low-birth-weight developing female rats" published in the recent issue of the Journal.[1] The authors investigated the effects of a high-fat, high-energy diet (HFHE diet) on the hepatic expression of CYP3A in low-birth-weight developing female rats. And they concluded that an HFHE diet can result in alterations of CYP3A expression in a developmental low birth-weight rat model. I have some concerns for Ni et al's study. Firstly, why the study only performed in female rats? The authors did not explain the reason they only select the female rats for this study. How about the effects of HFHE on male rats? It is very important for the authors to discuss this issue in the paper. In my view, the results obtained from only male rats may have some bias. Sugatani et al[2] found that mRNA levels of CYP3A1/2 were markedly decreased in HF dietfed and fluvastatin-treated rats. Yoshinari et al[3] showed that one-week administration of a high-fat diet in rats also reduced hepatic CYP3As. Secondly, the authors described the hepatic index as liver weight per unit of body weight, however the correct form for the relative hepatic weight is using the tibial length. Yin et al[4] performed a study on using tibial length to quantify cardiac hypertrophy. Under conditions in which body weight changes, relative hepatic weight can be more accurately quantified by relating hepatic weight to tibial length than to body weight; and this approach can be used for assessing relative sizes of other organs as well.[4] Ni et al[1] used body weight to quantify hepatic weight in their study. However, the diet used in the study may have affected body weight a lot. Therefore, the relative hepatic weight in their study may be not so accurate. Xiu-Juan Yang Department of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China Email: [email protected]
References
1 Ni SQ, Lou Y, Wang XM, Shen Z, Wang J, Zhao ZY, et al. A high-fat high-energy diet influences hepatic CYP3A expression 186
and activity in low-birth-weight developing female rats. World J Pediatr 2016;12:489-497. 2 Sugatani J, Sadamitsu S, Kurosawa M, Ikushiro S, Sakaki T, Ikari A, et al. Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats. Drug Metab Dispos 2010;38:1655-1664. 3 Yoshinari K, Takagi S, Yoshimasa T, Sugatani J, Miwa M. Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet. Pharm Res 2006;23:1188-1200. 4 Yin FC, Spurgeon HA, Rakusan K, Weisfeldt ML, Lakatta EG. Use of tibial length to quantify cardiac hypertrophy: application in the aging rat. Am J Physiol 1982;243:H941-H947. doi: 10.1007/s12519-017-0022-9
W
e wrote the paper entitled "A high-fat highenergy diet influences hepatic CYP3A expression and activity in low-birth-weight developing female rats". [1] As sex has influence on the ex
Data Loading...
