Retrospective study of the functional and oncological outcomes of conformal sphincter preservation operation in the trea
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ORIGINAL ARTICLE
Retrospective study of the functional and oncological outcomes of conformal sphincter preservation operation in the treatment of very low rectal cancer G. Sun1,3 · Z. Lou1 · H. Zhang1 · G. Y. Yu1 · K. Zheng1 · X. H. Gao1 · R. G. Meng1 · H. F. Gong1 · E. J. B. Furnée3 · C. G. Bai2 · W. Zhang1 Received: 14 June 2019 / Accepted: 18 April 2020 © The Author(s) 2020
Abstract Background Conformal sphincter preservation operation (CSPO) is a new surgical procedure for very low rectal cancers (within 4–5 cm from the anal verge). CSPO preserves more of the dentate line and distal rectal wall and also avoids injuring nerves in the intersphincteric space, resulting in satisfactory anal function after resection. The aim of this study was to analyze the short-term surgical results and long-term oncological and functional outcomes of CSPO. Methods Consecutive patients with very low rectal cancer, who had CSPO between January 2011 and October 2018 at Changhai Hospital, Shanghai were included. Patient demographics, clinicopathological features, oncological outcomes and anal function were analyzed. Results A total of 102 patients (67 men) with a mean age of 56.9 ± 10.8 years were included. The median distance of the tumor from the anal verge was 3 (IQR, 3–4) cm. Thirty-five patients received neoadjuvant chemoradiation (nCRT). The median distal resection margin (DRM) was 0.5 (IQR, 0.3–0.8) cm. One patient had a positive DRM. All circumferential margins were negative. There was no perioperative mortality. The postoperative complication rate was 19.6%. The median duration of follow-up was 28 (IQR, 12–45.5) months. The local recurrence rate was 2% and distant metastasis rate was 10.8%. The 3-year overall survival and disease-free survival rates were 100% and 83.9%, respectively. The mean Wexner incontinence and low anterior resection syndrome scores 12 months after ileostomy reversal were 5.9 ± 4.3, and 29.2 ± 6.9, respectively. Conclusions For patients with very low rectal cancers, fecal continence can be preserved with CSPO without compromising oncological results. Keywords Rectal neoplasms · Surgery · Disease-free survival · Postoperative complications · Margins of excision · Follow-up studies · Neoplasm recurrence · Local · Low anterior resection syndrome
Introduction
G. Sun and Z. Lou contributed equally to this work. * W. Zhang [email protected] 1
Department of Colorectal Surgery, Changhai Hospital, 168 Changhai Rd, Shanghai 200433, China
2
Department of Pathology, Changhai Hospital, Shanghai, China
3
Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands
Very low rectal cancer within 4–5 cm from the anal verge has traditionally been treated by abdominoperineal resection (APR) with acceptable oncological results [1, 2]. However, a permanent stoma decreases patients’ quality of life significantly [3]. With the advancement of surgical oncology and instrumentation, intersphincteric resection (ISR) and coloanal anastomosis (CAA) have gained widespread accep
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