Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis
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ASSISTED REPRODUCTION TECHNOLOGIES
Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis Jose Moreno - Sepulveda 1,2 & Miguel A. Checa 1,3 Received: 24 March 2019 / Accepted: 26 July 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Research question In women with singleton pregnancies conceived after assisted reproductive technologies, does the in vitro fertilization with oocyte donation (IVF-OD) affect the perinatal and maternal outcomes compared to autologous in vitro fertilization (IVF-AO)? Design Systematic review and meta-analysis of studies comparing perinatal and maternal outcomes in singleton pregnancies resulting from IVF-OD versus IVF-AO. An electronic literature search in Pubmed, MEDLINE, and Cochrane database was performed. The main outcome measures were hypertensive disorders in pregnancy, preeclampsia, severe preeclampsia, pregnancy-induced hypertension, preterm birth, early preterm birth, low birth weight, and very low birth weight. Results Twenty-three studies were included. IVF-OD is associated with a higher risk of hypertensive disorders in pregnancy (OR 2.63, 2.17–3.18), preeclampsia (OR 2.64; 2.29–3.04), severe preeclampsia (OR 3.22; 2.30–4.49), pregnancy-induced hypertension (OR 2.16; 1.79–2.62), preterm birth (OR 1.57; 1.33–1.86), early preterm birth (OR 1.80; 1.51–2.15), low birth weight (OR 1.25, 1.20–1.30), very low birth weight (OR 1.37, 1.22–1.54), gestational diabetes (OR 1.27; 1.03–1.56), and cesarean section (OR 2.28; 2.14–2.42). There was no significant difference in the risk of preterm birth or low birth weight when adjusted for preeclampsia. Conclusions IVF-OD patients should be considered an independent risk factor for some adverse perinatal outcomes, mainly hypertensive disorders in pregnancy, preeclampsia, and severe preeclampsia. Immunological and hormonal aspects may be involved in these results, and further research focusing in the etiopathogenesis of these pathologies are needed. Keywords In vitro fertilization . Oocyte donation . Preeclampsia . Preterm birth . Low birth weight
Introduction An increasing number of women of advanced reproductive age are seeking out assisted reproductive treatments (ART) [1, 2]. Around the world in 2011, 24% of autologous in vitro
fertilization (IVF-AO) were performed by women over 40, with a success rate of 5%. During the last European report in 2014, a live birth rate of 8% was reported [3, 4]. For women 45 years of age or older, the success rate is less than 1% [5].
Responsible editor: Claudio Bini Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10815-019-01552-4) contains supplementary material, which is available to authorized users. * Jose Moreno - Sepulveda [email protected] Miguel A. Checa [email protected] 1
Obstetrics and Gynecology Department, Parc de Salut Mar, Universitat Autonoma de Barcelona, Campus Universitario UAB, 08193 Bellaterra, Cerdanyola del Vallès, Balmes 10, 1-1, 08007 Barcelona, Sp
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