Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory d
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RESEARCH
Risks of ventilator‑associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease Keyvan Razazi1,2*, Romain Arrestier1,2 , Anne Fleur Haudebourg1,2, Brice Benelli1,2, Guillaume Carteaux1,2,3, Jean‑Winoc Decousser4,5,6, Slim Fourati5, Paul Louis Woerther5,6, Frederic Schlemmer3,7, Anais Charles‑Nelson8, Francoise Botterel5,6†, Nicolas de Prost1,2,3† and Armand Mekontso Dessap1,2,3
Abstract Background: Data on incidence of ventilator-associated pneumonia (VAP) and invasive pulmonary aspergillosis in patients with severe SARS-CoV-2 infection are limited. Methods: We conducted a monocenter retrospective study comparing the incidence of VAP and invasive aspergil‑ losis between patients with COVID-19-related acute respiratory distress syndrome (C-ARDS) and those with non-SARSCoV-2 viral ARDS (NC-ARDS). Results: We assessed 90 C-ARDS and 82 NC-ARDS patients, who were mechanically ventilated for more than 48 h. At ICU admission, there were significantly fewer bacterial coinfections documented in C-ARDS than in NC-ARDS: 14 (16%) vs 38 (48%), p
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