Role of gut microbiota in identification of novel TCM-derived active metabolites
- PDF / 1,419,517 Bytes
- 17 Pages / 595.276 x 785.197 pts Page_size
- 7 Downloads / 144 Views
Protein & Cell
REVIEW Role of gut microbiota in identification of novel TCM-derived active metabolites Tzu-Lung Lin1, Chia-Chen Lu2,3, Wei-Fan Lai4, Ting-Shu Wu4,5,6, Jang-Jih Lu5,6, Young-Mao Chen7, Chi-Meng Tzeng8, Hong-Tao Liu9, Hong Wei10, Hsin-Chih Lai1,5,6,11,12& Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan 33302, Taiwan, China 2 Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City 24205, Taiwan, China 3 Department of Chest Medicine, Internal Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City 24205, Taiwan, China 4 Department of Medicine, Chang Gung University, Taoyuan 33302, Taiwan, China 5 Department of Laboratory Medicine and Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan, China 6 Central Research Laboratory, Xiamen Chang Gung Hospital, Xiamen 361026, China 7 Bachelor Degree Program in Marine Biotechnology, College of Life Sciences, National Taiwan Ocean University, Keelung 20224, Taiwan, China 8 School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China 9 College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan 430065, China 10 Central Laboratory, Clinical Medicine Scientific and Technical Innovation Park, Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200435, China 11 Microbiota Research Center and Emerging Viral Infections Research Center, Chang Gung University, Taoyuan 33302, Taiwan, China 12 Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Gueishan, Taoyuan 33303, Taiwan, China & Correspondence: [email protected] (H.-C. Lai) Received March 13, 2020 Accepted May 29, 2020
ABSTRACT Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic
Tzu-Lung Lin and Chia-Chen Lu have contributed equally.
© The Author(s) 2020
activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.
KEYWORDS Traditional Chinese Medicine, herbs, microbiota, transformation, multiomics
INTRODUCTION TCM and herbal formulae TCM has been used for centuries
Data Loading...
