Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy
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(2020) 20:592
RESEARCH ARTICLE
Open Access
Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy Longhuan Zeng†, Xueying Cai†, Jiayi Chen, Guangyong Jin and Yongke Zheng*
Abstract Background: Hypertriglyceridemia-induced acute pancreatitis during pregnancy (HTG-APP) is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-APP remains unclear. Methods: In the retrospective study, we collected 45 patients with HTG-APP as the HTG-APP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared. Results: MPV were significantly higher in the HTG-APP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010). Logistic regression analyses revealed that MPV was significantly associated with SAP (odds ratio = 2.077, 95% confdence interval, 1.038–4.154; P = 0.039). Conclusions: These results may indicate an important role of mean platelet volume in evaluating the severity of HTG-APP. Keywords: Hypertriglyceridemia-induced acute pancreatitis, Pregnancy, Mean platelet volume, Diagnosis, Severity
Background Acute pancreatitis during pregnancy (APP) is a rare, but life-threatening disease with an estimated incidence of approximately 3–10/10,000 [1, 2]. AP can result in multiple organ dysfunction and disseminated intravascular coagulation owing to activation of the inflammatory and coagulation systems. Moreover, pregnancy-related physiologic alterations influence the diagnosis and management of many diseases. Therefore, APP can severely
* Correspondence: [email protected] † Longhuan Zeng and Xueying Cai contributed equally to the study Department of Intensive Care Unit, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 261 Huansha Road, 310006 Hangzhou, Zhejiang, China
affect the mother and fetus and lead to a higher risk of intrauterine fetal death. The most common cause of APP is gallstones, followed by alcohol abuse, hypertriglyceridemia, and unknown causes [3]. Non-gallstone pancreatitis is thought to be related to more complications and a poorer prognosis, such as hypertriglyceridemia-induced AP (HTG-AP) [4]. Mean platelet volume (MPV) is a blood parameter used for measuring platelet size and is accepted as a widely used indicator of thrombocytic activity. In addition, MPV has been investigated in various thrombotic and inflammatory diseases [5]. To date, there hav
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