Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome
- PDF / 163,443 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 95 Downloads / 218 Views
ORIGINAL ARTICLE
Serum cystatin C predicts acute kidney injury in preterm neonates with respiratory distress syndrome Ahmet Taner Elmas & Yilmaz Tabel & Özlem Nalbantoğlu Elmas
Received: 12 July 2012 / Revised: 19 September 2012 / Accepted: 19 September 2012 / Published online: 16 October 2012 # IPNA 2012
Abstract Background We aimed to compare serum cystatin C levels (sCysC) in preterm neonates with respiratory distress syndrome (RDS) with a control group and to investigate whether it could be used as a predictor for acute kidney injury (AKI). Methods sCysC was measured in 62 neonates with RDS (n028) and control neonates without RDS (n034), whose gestational ages (GA) were between 27 and 29 weeks (subgroup 1) and 30–32 weeks (subgroup 2). AKI was defined as oliguria and/or increase of serum creatinine. Blood samples were obtained on postnatal days (PND) 3 and 30. sCysC levels were determined by particle-enhanced nephelometric immunoassay. Results There were six neonates with AKI (RDS-AKI subgroup) and 22 neonates without AKI (RDS-no AKI subgroup) during the first 7 days. Although sCysC levels were lower in neonates with RDS than controls on PND3 in both GA subgroups, the differences were not significant. However, in neonates with RDS and AKI, sCysC levels were significantly higher than neonates with RDS but no AKI and neonates in the control group on PND3. sCysC level was found to have a statistically significant association with AKI development in preterm neonates with RDS. A. T. Elmas : Y. Tabel Department of Pediatric Nephrology, Faculty of Medicine, University of Inonu, Malatya, Turkey Ö. N. Elmas Department of Pediatrics, State Hospital, Malatya, Turkey Y. Tabel (*) Inonu Universitesi, Turgut Ozal Tip Merkezi, Cocuk Sagligi ve Hast. AD, 44280 Malatya, Turkey e-mail: [email protected]
Conclusions sCysC is an independent predictor of AKI in preterm neonates with RDS. Keywords Preterm . Neonates . Respiratory distress syndrome . Acute kidney injury . Serum cystatin C
Introduction One of the most frequent forms of respiratory failure in preterm neonates is respiratory distress syndrome (RDS). RDS is a common cause of neonatal death and disability [1], and almost 50 % of neonates with birth weight (BW) under 1,500 g are affected by RDS [2]. Despite recent advances in perinatal and neonatal care in RDS prevention and treatment, a considerable number of these neonates suffer from acute kidney injury (AKI), and it is associated with poor outcome as an independent risk factor [3, 4]. Because there is no universal criterion for AKI definition, reports on the incidence of the disease range between 8 and 24 % of neonatal intensive care unit (NICU) admissions [5]. Therefore, early detection of the disease would contribute to efforts for better neonatal outcome in NICU. High serum creatinine levels (Cr) are widely used in the diagnosis of AKI [6, 7]. However, there are a number of drawbacks supporting the claim that this scheme might not be satisfactory, since (1) Cr does not measure injury but only function [8]
Data Loading...
