Short-term use of the implantable contraceptive Implanon may reduce high-molecular-weight adiponectin (HMW) levels in he
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■ Short-term use of the implantable contraceptive Implanon may reduce high-molecular-weight adiponectin (HMW) levels in healthy premenopausal women, according to a longitudinal study conducted in Switzerland. HMW suppresses endothelial cell apoptosis, and low levels of the isomer are considered to be unfavourable with regard to cardiovascular risk. While the low-dose etonogestrel-releasing contraceptive, Implanon, was shown not to affect overall adiponectin plasma concentrations; after 3 months, women using Implanon experienced significant decreases in HMW levels and decreases in the HMW/total-adiponectin ratio versus baseline. Merki-Feld GS, et al. Implanon use lowers plasma concentrations of highmolecular-weight adiponectin. Fertility and Sterility : 22 Jun 2010. Available 803032660 from: URL: http://dx.doi.org/10.1016/j.fertnstert.2010.05.018
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Reactions 21 Aug 2010 No. 1315
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