Sofosbuvir
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Small vessel vasculitis complicated by crescentic glomerulonephritis: case report A 65-year-old woman developed small vessel vasculitis complicated by crescentic glomerulonephritis following treatment with sofosbuvir for hepatitis C virus (HCV) infection. The woman, who had controlled type 2 diabetes mellitus, was diagnosed with HCV infection. She then received a 3-month course of sofosbuvir [dosage and route not stated], daclatasvir and ribavirin, and a sustained viral response (SVR) was noted. After 3 months of the treatment completion, she presented with puffiness, bilateral lower extremities oedema and vomiting in 2019. Her laboratory investigations were significant for acute kidney injury, haematuria and nephrotic proteinuria. Kidney biopsy showed focal necrotising glomerulonephritis with 70% crescents. Based on the findings, small vessel vasculitis complicated by crescentic glomerulonephritis was considered. The woman was treated with methylprednisolone, prednisolone and cyclophosphamide, and a clinical improvement was observed. However, she developed bone marrow suppression [aetiology not stated]. Thus, cyclophosphamide was stopped. Subsequently, she started receiving valsartan to control proteinuria with slight increase in serum creatinine to 1.4 mg/dL. It was concluded that her small vessel vasculitis was associated with sofosbuvir use. Elrggal M, et al. Crescentic glomerulonephritis following HCV treatment with daas, the non-classic tale. Nephrology Dialysis Transplantation 35 (Suppl. 3): iii784-iii785 803520290 abstr. P0475, Jun 2020. Available from: URL: http://doi.org/10.1093/ndt/gfaa142.P0475 [abstract]
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Reactions 12 Dec 2020 No. 1834
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