Spinal cord involvement in Kearns-Sayre syndrome: a neuroimaging study
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PAEDIATRIC NEURORADIOLOGY
Spinal cord involvement in Kearns-Sayre syndrome: a neuroimaging study Pasquini Luca 1,2 & Guarnera Alessia 1,2 & Rossi-Espagnet Maria Camilla 1,2 & Napolitano Antonio 3 & Martinelli Diego 4 & Deodato Federica 4 & Diodato Daria 5 & Carrozzo Rosalba 5 & Dionisi-Vici Carlo 4 & Longo Daniela 1 Received: 23 April 2020 / Accepted: 14 July 2020 # The Author(s) 2020
Abstract Purpose Spinal cord involvement in Kearns-Sayre (KSS) syndrome could be more frequent than commonly thought. Our aims were to evaluate the involvement of the spinal cord in patients with KSS by means of MRI and to investigate possible correlations of spinal and brain disease with patient disability. Methods Eleven patients with KSS disease and spinal cord MRI were retrospectively recruited. The severity of spinal disease was defined as follows: grade 0 (none), grade 1 (focal), and grade 2 (extensive). We calculated a radiologic score of brain involvement based on typical features. We performed a chi-square test to correlate spinal cord and brain MRI involvement to patient disability. For significant variables, a contingency coefficient, phi factor, and Cramer’s V were also computed. Results Spinal cord lesions were detected in 6/11 patients, showing four patterns: involvement of gray matter, gray matter and posterior columns, posterior columns, and anterior columns. The severity of spinal disease was grade 1 in two and grade 2 in four patients. All patients showed brain involvement (9-point average for patients with spinal involvement and 10 for the others). A significant correlation was found between disability score and spinal cord involvement (χ2 = 7.64; p = 0.022) or brain score (χ2 = 26.85; p = 0.043). Significance for brain score-disability correlation increased with the spinal cord as a cofactor (χ2 = 24.51; p = 0.017, phi factor = 1.201, Cramer’s V = 0.849, contingency effect = 0.767; p = 0.017). Conclusion Spinal cord lesions are common in KSS. Patients with spinal disease show higher disability than patients without spinal cord lesions, supporting the inclusion of dedicated acquisitions to routine MRI of the brain in patients with KSS. Keywords Kearns-Sayre syndrome . Spinal cord . MRI . Mitochondrial disease
Introduction * Pasquini Luca [email protected] 1
Neuroradiology Unit, Imaging Department, Bambino Gesù Children’s Hospital, P.zza Sant’Onofrio 4, 00165 Rome, Italy
2
Neuroradiology Unit, NESMOS Department, Sant’Andrea Hospital, La Sapienza University, Rome, Italy
3
Medical Physics Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
4
Division of Metabolism, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy
5
Unit of Muscular and Neurodegenerative Disorders, Laboratory of Molecular Medicine, IRCCS Bambino Gesù Children’s Hospital, 00146 Rome, Italy
The Kearns-Sayre syndrome (KSS) is a rare mitochondrial encephalopathy, with an estimated prevalence of around 1/125,000 [1]. The syndrome is characterized by onset before 20 years of age and a typical clinical triad: pigmentary retin
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