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S Phase

Saltatory Nerve Conduction

Definition

Definition

S phase describes the cell cycle phase during which DNA replication occurs and centrosomes duplicate. ▶Cell Cycle – Overview

Saltatory nerve conduction refers to transmission of impulses along myelinated axons in vertebrates, with action potentials restricted to the ▶Nodes of Ranvier. ▶Glial Cells and Myelination

S-Acylation ▶Thioester-Linkage

SAD ▶Single-Wavelength Anomalous Diffraction

Salvage Pathway Definition Salvage pathway refers to a short sequence of enzymecatalyzed reactions in the purine and pyrimidine metabolism which uses preformed purine or pyrimidine bases, or nucleosides to form nucleotides. ▶Nucleotide Biosynthesis

SAMP Repeats Definition

SAGA Definition SAGA is a yeast histone acetyltransferases complex Spt/Ada/Gcn5. ▶Polyglutamine Disease, the Emerging Role of Transcription Interference

SAMP repeats are found three times in the tumor suppressor APC, and serve as binding sites for axin/ conductin. SAMP repeats are about 30 amino acids long and contain at their core the invariant Ser-AlaMet-Pro sequence. ▶Colorectal Cancer

Sampling SAGE ▶Serial Analysis of Gene Expression

Definition Sampling designates the process of generating configurations for a given system. ▶Molecular Dynamics Simulation in Drug Design

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Sanger Sequencing Method

Sanger Sequencing Method

SARA

Definition

Definition

In contrast to the Maxam/Gilbert-Method of DNAsequencing that is based on base-specific chemical modification, cleavage of the DNA at the modified sites, electrophoresis of the fragments, and autoradiography of the sequencing, the method of Sanger (also known as the dideoxychain termination method) is based on hybridisation by a short primer, synthesis by DNA-polymerase In the presence of desoxynucleosidhtriphosphates, stop of synthesis by addition of 2′3′–didesoxynucleosidtriphosphates, electrophoreses of the cleavage products, and autoradiography. The method of Sanger developed by Frederick Sanger and co-workers is the most common DNA sequencing method. ▶SNP Detection and Mass Spectrometry

▶Smad anchor for receptor activation (SARA) is a protein that binds to phospholipids in the membrane of the early endosome via its FYVE domain, and also binds to Smad2, Smad3 and TbRI, thus mediating the phosphorylation of Smads by Type I ▶RSKs. SARA is also thought to act as an anchor of Smads in the cytoplasm, inhibiting their intrinsic ability to translocate into the nucleus. ▶Receptor Serine/Threonine Kinases

SAR-by NMR Definition

Sanglifehrin

Structure activity relationship (SAR) by NMR is a drug discovery and design strategy developed by Fesik and co-workers, which involves NMR-based screening of compound libraries followed by chemically combining weakly interacting compounds. ▶3D Structure by NMR

Definition Sanglifehrin is a 22–membered macrocycle isolated from the actinomyocyte Streptomyces sp. A92– 308110. It shows strong affinity for members of the ▶cyclophilin family with peptidyl-prolyl isomerase activity (PPIase). It has immunosuppre