Studies on the Control of Pineal Indole Synthesis: Cyclic Nucleotides, Adenylate Cyclase and Phosphodiesterase
An overview of the biochemical events that occur when postsynaptic pineal beta-adrenergic receptors are stimulated is presented. Emphasis is placed on the importance of the adenylate cyclase system for the induction of N-acetyltransferase (NAT). Super- an
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Journal of Neural Transmission Supplementum 13
The Pineal Gland Proceedings of the International Symposium, Jerusalem, November 14-17, 1977
Edited by I. Nir, R. J. Reiter, and R. J. Wurtman
Springer-Verlag Wien GmbH
Professor Isaac Nir
Department of Pharmacology Faculty of Medicine Hadassah Medical Center Jerusalem, Israel
Professor Rüssel J. Reiter Department of Anatomy The University of Texas San Antonio, Texas, USA
Professor Richard J. Wurtman
Laboratory of Neuroendocrine Regulation Department of Nutrition and Food Science Massachusetts Institute of Technology Cambridge, Massachusetts, USA
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. © 1978 by Springer-Verlag Wien Ursprünglich erschienen bei Springer-Verlag/Wien 1978 Softcover reprint of the hardcover 1st edition 1978
With 79 Figures
Library of Congress Cataloging in Publication Data. Main entry under title: The Pineal gland. (Journal of neural transmission : Supplementum ; 13.) 1. Pineal body-Congresses. 2. Melatonin-Congresses. I. Nir, Isaac, 1916— . II. Reiter, Rüssel J. III. Wurtman, Richard J. IV. Series. [DNLM: 1. Pineal body-Congresses. 2. Melatonin-Congresses. 3. Hormones-Congresses. Wl JO781A no. 13 / WK350 P649 1977]. QP188.P55P56. 596'.01'88. 78-23416 ISBN 978-3-7091-4429-9 DOI 10.1007/978-3-7091-4427-5
ISBN 978-3-7091-4427-5 (eBook)
Contents Opening Remarks
1
0
Brainard, G. c.: Pineal Research: The Decade of Transformation
0
3
Session 1: Functional Anatomy of the Pineal Ariens Kappers, J.: Localization of Indoleamine and Protein Synthesis in the Mammalian Pineal Gland (Chairman's Introduction)
13
Ralph, C.1.: Cytology of the Pineal Gland: Changes Produced by Various Treatments
25
Moore, R. Yo: Neural Control of Pineal Function in Mammals and Birds
47
Wurtman, R. J., Ozaki, Y.: Physiological Control of Melatonin Synthesis and Secretion: Mechanisms Generating Rhythms in Melatonin, Methoxytryptophol, and Arginine Vasotocin Levels and Effects on the Pineal of Endogenous Catecholamines, the Estrous Cycle, and Environmental Lighting
59
0
0
Session 2: Regulation of Pineal Synthesis Axelrod, J.: Introductory Remarks on Regulation of Pineal Indoleamine Synthesis (Chairman's Introduction)
73
Oleshansky, M. A., Neff, N. H.: Studies on the Control of Pineal Indole Synthesis: Cyclic Nucleotides, Adenylate Cyclase and Phosphodiesterase
81
Zatz, M: Sensitivity and Cyclic Nucleotides in the Rat Pineal Gland
97
Deguchi, T.: Ontogenesis of Circadian Rhythm of Melatonin Synthesis in Pineal Gland of Rat
115
0
0
VI
Contents
Session 3: Possible Pineal Hormones Other Than Melatonin Lerner, A. B.: Hormones in the Pineal Other Than Melatonin (Chairman's Introduction) .
131
Pavel, S.: Arginine Vasotocin as a Pineal Hormone
135
Benson, B., Ebels, I.: Pineal Peptides .
157
Cardinali, D. P., Va
