Subacute Inflammatory Activation in Subjects with Acute Coronary Syndrome and Left Ventricular Dysfunction
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Subacute Inflammatory Activation in Subjects with Acute Coronary Syndrome and Left Ventricular Dysfunction Luisa De Gennaro,1 Natale Daniele Brunetti,1,2 Deodata Montrone,1 Fiorella De Rosa,1 Andrea Cuculo,1 and Matteo Di Biase1
Abstract—Several lines of evidence indicate that increased inflammatory cytokine levels can be used for risk prediction in patients with acute coronary syndrome (ACS). This study therefore aimed to evaluate correlations between levels of soluble interleukin (IL)-2 receptor (sIL-2r), IL-6, and IL-8 and in-hospital incidence of acute heart failure (AHF) and left ventricular (LV) systolic dysfunction in the subacute phase of ACS. In 48 consecutive patients with ACS, circulating levels of sIL-2r, IL6, and IL-8 were ascertained 72–96 h after onset of symptoms. Clinical data, LV function, and inhospital incidence of AHF were also evaluated. IL-8 levels were significantly higher in patients with pulmonary edema (1,829±2,496 vs 456±624 pg/ml, p
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