Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: a SEER-based study
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RESEARCH ARTICLE
Open Access
Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: a SEER-based study Jia Huang1,2†, Guodong Chen3†, Huan Liu3, Yiwei Zhang3, Rong Tang4, Qiulin Huang4, Kai Fu5*, Xiuda Peng6* and Shuai Xiao1,4*
Abstract Background: Mucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and metastases for CLM patients would be beneficial. However, there is still no consensus on the role of surgery for MC with liver metastases (M-CLM). Methods: Patients diagnosed with M-CLM or classical adenocarcinoma with CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analysed. Results: The results showed that the M-CLM group had a larger tumour size, more right colon localizations, higher pT and pN stages, more female patients, and more retrieved and positive lymph nodes and accounted for a higher proportion of surgeries than the A-CLM group. The OS and CSS of M-CLM patients who underwent any type of surgery were significantly better than those of patients who did not undergo any surgery, but poorer than those of A-CLM patients who underwent surgery. Meanwhile, the OS and CSS of M-CLM and A-CLM patients who did not undergo any surgery were comparable. Compared with hemicolectomy, partial colectomy led to similar or better OS and CSS for M-CLM, and surgery was an independent protective factor for long-term survival in M-CLM. Conclusions: M-CLM had distinct clinicopathological characteristics from A-CLM, and surgery could improve the survival and is an independent favourable prognostic factor for M-CLM. In addition, partial colectomy might be a non-inferiority choice as hemicolectomy for M-CLM according to the results from this study. Keywords: Colon carcinoma, Mucinous adenocarcinoma, Liver metastases, Surgery, Survival
* Correspondence: [email protected]; [email protected]; [email protected] † Jia Huang and Guodong Chen contributed equally to this work. 5 Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, and Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China 6 Department of Surgery of the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People’s Republic of China 1 Institute of Clinical Medicine of the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People’s Republic of China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as
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