Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines
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Medicinal Chemistry Research https://doi.org/10.1007/s00044-020-02638-w
ORIGINAL RESEARCH
Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines Chekuri Sharmila Rani1 Alugubelli Gopi Reddy2 E. Susithra3 Kit-Kay Mak4 Mallikarjuna Rao Pichika4 Sreenivasulu Reddymasu5 Mandava Venkata Basaveswara Rao1 ●
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Received: 19 June 2020 / Accepted: 17 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract A novel series of amide functionalized imidazo[1,2-a]pyridine (14a–14j) derivatives were synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB-231), lung (A549), and prostate (DU-145) cancer cell lines using MTT assay with etoposide as the standard reference drug. Among them, compound 14j showed highest potency in anticancer activities against MCF-7, MDA-MB-231, A549, and DU-145 cell lines with IC50 values of 0.021 ± 0.0012 µM, 0.95 ± 0.039 µM, 0.091 ± 0.0053 µM, and 0.24 ± 0.032 µM, respectively. Keywords Zolpidem Alpidem Imidazo[1,2-α]pyridine Crizotinib Pyridine and anticancer activity ●
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Introduction Cancer is a dangerous disease and second leading cause of death in both undeveloped and developed countries [1]. During the year 2015, in USA, 1,658,370 cancer cases were registered and 589,430 deaths were reported [2]. In India, the total number of registered cancer cases increased from 979,786 to 1,148,757 over 10-year time period (2010–2020) [3]. In spite of some advancement in interpreting the mechanism of cancer pathogenesis, yet there is
Supplementary information The online version of this article (https:// doi.org/10.1007/s00044-020-02638-w) contains supplementary material, which is available to authorized users. * Mandava Venkata Basaveswara Rao [email protected] 1
Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh 521001, India
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Department of Pharmacy, SANA College of Pharmacy, Kodad, Telangana 508206, India
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Department of Pharmacy, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, India
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Pharmaceutical Chemistry Department, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
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Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh 533003, India
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no particular special treatment that is improved for destroying the cancer cell lines. In general, nitrogen-based heterocyclic scaffolds act as promising anticancer agents against a panel of cancer cell lines ([4–23]; Madhavi et al. [24–26]; Pragathi et al. [27]). Imidazo[1,2-α]pyridines are nitrogen containing fused bicyclic hetero-aromatic essential compounds [28] and are found in many biologically active compounds [29]. These molecules have shown a broad range of biological activities such as CDK inhibition [30, 31], anticancer [32], antifungal [33], antitubercular [34], antiviral [35],
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