Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of
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Systematic assessment of venous thromboembolism in COVID‑19 patients receiving thromboprophylaxis: incidence and role of D‑dimer as predictive factors Mathieu Artifoni1 · Gwenvael Danic1 · Giovanni Gautier1 · Pascal Gicquel2 · David Boutoille3,4 · François Raffi3,4 · Antoine Néel1,5 · Raphaël Lecomte3,4
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Coagulopathy in COVID-19 is a burning issue and strategies to prevent thromboembolic events are debated and highly heterogeneous. The objective was to determine incidence and risk factors of venous thromboembolism (VTE) in COVID-19 inpatients receiving thromboprophylaxis. In this retrospective French cohort study, patients hospitalized in medical wards non-ICU with confirmed COVID-19 and adequate thromboprophylaxis were included. A systematic low limb venous duplex ultrasonography was performed at hospital discharge or earlier if deep venous thrombosis (DVT) was clinically suspected. Chest angio-CT scan was performed when pulmonary embolism (PE) was suspected. Of 71 patients, 16 developed VTE (22.5%) and 7 PE (10%) despite adequate thromboprophylaxis. D-dimers at baseline were significantly higher in patients with DVT (p
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