Systematic literature review on novel corona virus SARS-CoV-2: a threat to human era
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REVIEW ARTICLE
Systematic literature review on novel corona virus SARS-CoV-2: a threat to human era Dinesh Kumar Rajendran1 • Varthini Rajagopal2 • S. Alagumanian3 • T. Santhosh Kumar4 • S. P. Sathiya Prabhakaran5 • Dharun Kasilingam6
Received: 4 April 2020 / Accepted: 24 May 2020 Ó Indian Virological Society 2020
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the seventh-generation coronavirus family causing viral pandemic coronavirus disease (COVID-19) across globe affecting millions of people. The objectives of this study are to (1) identify the major research themes in COVID-19 literature, (2) determine the origin, symptoms and modes of transmission of COVID, (3) recommend the intervention and mitigation strategies adopted by the Governments globally against the spread of COVID-19 and the traumatization among the public? and (4) study the possible drugs/treatment plans against COVID-19. A systematic literature review and comprehensive analysis of 38 research articles on COVID-19 are conducted. An integrated Research focus parallel-ship network and keyword co-occurrence analysis are carried out to visualize the three research concepts in COVID-19 literature. Some of our observations include: (1) as SARSElectronic supplementary material The online version of this article (https://doi.org/10.1007/s13337-020-00604-z) contains supplementary material, which is available to authorized users. & Varthini Rajagopal [email protected] 1
Department of Mechanical Engineering, National Institute of Technology Goa, Goa, India
2
Department of Mechanical Engineering, Government College of Engineering Srirangam, Tiruchirappalli, Tamilnadu, India
3
Department of Botany, H.H. The Rajah’s College, Pudukkottai, Tamilnadu, India
4
Department of Pediatrics, JIPMER, Pondicherry, India
5
Department of Energy and Environment Engineering, NITTiruchirappalli, Tiruchirappalli, India
6
Digital Platform and Strategies, MICA The School of Ideas, Ahmedabad, India
CoV-2’s RNA matches * 96% to SARS-CoV, it is assumed to be transmitted from the bats. (2) The common symptoms are high fever, dry cough, fatigue, sputum production, shortness of breath, diarrhoea etc. (3) A lockdown across 180 affected counties for more than a month with social-distancing and the precautions taken in SARS and MERS are recommended by the Governments. (4) Researchers’ claim that nutrition and immunity enhancers and treatment plans such as arbidol, lopinavir/ritonavir, convalescent plasma and mesenchymal stem cells and drugs including remdesivir, hydroxychloroquine, azithromycin and favipiravir are effective against COVID-19. This complied report serves as guide to help the administrators, researchers and the medical officers to adopt recommended intervention strategies and the optimal treatment/drug against COVID-19. Keywords SARS-CoV-2 Origin Symptoms Drugs Interventions Network analysis
Introduction Coronavirus (CoV) is clustered under the viral family group that causes disease in mammals and birds. A pandemic no
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