Tehran environmental and neurodevelopmental disorders (TEND) cohort study: Phase I, feasibility assessment
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RESEARCH ARTICLE
Tehran environmental and neurodevelopmental disorders (TEND) cohort study: Phase I, feasibility assessment Mansour Shamsipour 1 & Reihaneh Pirjani 2 & Maryam Zare Jeddi 3 & Mohammad Effatpanah 4 & Noushin Rastkari 5 & Homa Kashani 1 & Mahboobeh Shirazi 6 & Mohammad Sadegh Hassanvand 5 & NinoKünzli 7,8 & Mamak Shariat 9 & Fatemeh Sadat Javadi 10 & Ghazal Shariatpanahi 11 & Gholamreza Hassanpour 12 & Zahra Peykarporsan 13 & Akram Jamal 13 & Mina Ebad Ardestani 1 & Fatemeh Sadat Hoseini 14 & Hosein Dalili 15 & Fatemeh Sadat Nayeri 9 & Alireza Mesdaghinia 16 & Kazem Naddafi 5,13 & Seyed Jamaleddin Shahtaheri 17 & Simin Nasseri 13,16 & Farzad Yunesian 18 & Golnaz Rezaeizadeh 9 & Heresh Amini 19,20 & Kazuhito Yokoyama 21 & Mohsen Vigeh 9,21 & Masud Yunesian 1,13 Received: 25 October 2019 / Accepted: 15 June 2020 # Springer Nature Switzerland AG 2020
Abstract Purpose To advance knowledge about childhood neurodevelopmental disorders and study their environmental determinants, we conducted a study in Tehran, Iran to assess the feasibility of prospective birth cohort study. Methods We evaluated participation of pregnant women, feasibility of sampling biological material, and health care services availability in Tehran in four steps: (1) first trimester of pregnancy; (2) third trimester of pregnancy; (3) at delivery; and (4) two to three months after delivery. We collected related data through questionnaires, also various biological samples were obtained from mothers (blood, urine, milk and nails—hands and feet) and newborns (umbilical cord blood, meconium, and urine samples) from February 2016 to October 2017. Results overall 838 eligible pregnant women were approached. The participation rate was 206(25%) in our study and about 185(90%) of subjects were recruited in hospitals. Out of 206 participants in the first trimester, blood, urine, hand nail, and foot nail samples were collected from 206(100%),193(93%), 205(99%), and 205(99%), respectively. These values dropped to 65(54%), 83(69%), 84(70%), and 84(70%) for the remaining participants 120(58%) in the third trimester, respectively. Also, we gathered milk samples from 125(60%) of mothers at two to three months after delivery. Conclusion Our findings suggest that hospitals were better places for recruitment of subjects in a birth cohort in Tehran. We further concluded that birth cohort study recruitment can be improved by choosing appropriate gestational ages. Obtaining the newborn’s urine, meconium, and umbilical cord blood were challenging procedures and require good collaboration between hospital staff and researchers. Keywords Biomonitoring . Environmental chemicals . Birth cohort study . Iran
Introduction Environmental exposures during pregnancy and childhood may permanently change the body’s structure, physiology, and metabolism that can promote the risk of illness long time after the environmental exposure has occurred, even across * Mohsen Vigeh [email protected] * Masud Yunesian [email protected] Extended author information available on t
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