The comparison of spectral domain optical coherence tomography and indocyanine green angiography in the diagnosis of pol
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ORIGINAL PAPER
The comparison of spectral domain optical coherence tomography and indocyanine green angiography in the diagnosis of polypoidal choroidal vasculopathy Bilge Eraydin
. Nurullah Koc¸ak . Hakkı Birinci
Received: 20 July 2020 / Accepted: 5 October 2020 Ó Springer Nature B.V. 2020
Abstract Objectives To evaluate the diagnostic capability of spectral domain optical coherence tomography (SDOCT) in patients with potential diagnostic findings for polypoidal choroidal vasculopathy (PCV). Materials and methods Ninety-three eyes with potential diagnostic findings for PCV were prospectively evaluated. Patients with multiple retinal pigment epithelial detachment (RPED), sharp RPED peak, RPED notch, hyporeflective lumen representing polyps, double-layer sign and the presence of hyperreflective intraretinal hard exudate were considered as PCV in SD-OCT. The sensitivity and specificity of SD-OCT in the diagnosis of PCV were determined by comparing SD-OCT-based diagnosis with indocyanine green angiography (ICGA). Results Sixty-nine (74.2%) of 93 eyes included in the study were confirmed with ICGA and diagnosed as PCV. The sensitivity and specificity of SD-OCT for the diagnosis of PCV were 75.3% and 75%, respectively. Conclusion The SD-OCT-based method helps clinicians to develop appropriate diagnostic and treatment strategies for patients in whom ICGA cannot be used.
B. Eraydin (&) Tokat Erbaa State Hospital, Tokat, Turkey e-mail: [email protected] N. Koc¸ak H. Birinci Department of Ophthalmology, Ondokuz Mayıs University, Samsun, Turkey
Keywords Polypoidal choroidal vasculopathy SDOCT ICGA
Introduction Polypoidal choroidal vasculopathy (PCV) is a clinical entity characterised by multiple recurrent serosanguineous detachments of the retinal pigment epithelium and neurosensory retina secondary to leakage and bleeding from choroidal vascular lesions [1]. The disease usually presents with orange subretinal nodules in the macula or peripapillary region [2]. PCV has a higher prevalence in the Asian population, and it is frequently observed in men and unilateral [3]. While many studies have argued that PCV is a subgroup of neovascular age-related macular degeneration (n-AMD), there are also studies advocating that PCV is a different choroidal vasculopathy than n-AMD [4–6]. Furthermore, optical coherence tomography (OCT)-based imaging studies of PCV suggest that PCV may be included in the pachychoroid spectrum caused by pathology in the choroidal circulation [7]. Clinical manifestations of patients with PCV, overall visual prognosis, the natural history of the disease and evaluation of the group of patients at risk support that PCV is different from n-AMD [6, 8]. In addition, the differentiation of PCV from n-AMD is important because of the different management and treatment responses of these two diseases [9].
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Int Ophthalmol
In many cases, the co-use of OCT and fluorescein angiography (FA) is considered sufficient for the diagnosis of n-AMD, while mis
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