The global, regional, and national burden of kidney cancer and attributable risk factor analysis from 1990 to 2017
- PDF / 8,317,350 Bytes
- 15 Pages / 595.276 x 790.866 pts Page_size
- 90 Downloads / 176 Views
Experimental Hematology & Oncology Open Access
RESEARCH
The global, regional, and national burden of kidney cancer and attributable risk factor analysis from 1990 to 2017 Xianguang Bai1,2†, Ming Yi2†, Bing Dong3, Xinhua Zheng1* and Kongming Wu2,3*
Abstract Background: Kidney cancer’s incidence and mortality vary in different regions and countries. To compare and interpret kidney cancer’s burden and change trends in the globe and in different countries, we conducted this study to report the global kidney cancer burden and attributable risk factors. Methods: Data about kidney cancer’s incidence, death, disability-adjusted life-year (DALY) were extracted from the Global Burden of Diseases 2017. Besides, social-demographic index (SDI) values were adopted to investigate the correlation between kidney cancer’s burden and social development degrees. Results: In the globe, the incidence case of kidney cancer increased sharply from 207.31*103 in 1990 to 393.04*103 in 2017. High SDI countries had the highest kidney cancer’s burden with a decreased trend in incidence rate. On the contrary, the incidence rate was rapidly increased in low-middle SDI countries, although their burden of kidney cancer kept relatively low. At the same time, the deaths of kidney cancer increased from 68.14*103 to 138.53*103, and the kidney cancer-related DALYs increased from 1915.49*103 in 1990 to 3284.32*103 in 2017. Then, we searched the GBD database for kidney cancer-related risk factor. The high body-mass index and smoking were the main factors contributing to kidney cancer-related mortality. Conclusions: Generally, from 1990 to 2017, the incidence rate in developed countries had gone down from the historic peak values while the incidence rate was still on the rise in developing counties. Given the aging trend in the globe, it is necessary to appeal to the public to decrease the exposure of kidney cancer-associated risk factors. Keywords: Kidney cancer, Social-demographic index, Global burden of diseases, Cancer epidemiology, Attributable risk factor Background Kidney cancer is a common genitourinary malignancy with poor prognosis. In 2019, kidney cancer was the sixth most commonly diagnosed cancer in males and the eighth in females in the United States [1]. In *Correspondence: [email protected]; [email protected] † Xianguang Bai and Ming Yi contributed equally to this work 1 Medical School of Pingdingshan University, Pingdingshan, Henan, China 2 Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Full list of author information is available at the end of the article
general, the incidence of kidney cancer predominates in males, and the ratio of male to female is approximately 1.5:1 [2]. Besides, the incidence rate of kidney cancer varies in different countries, which is commonly higher in developed countries than in developing countries [3]. Although the incidence keeps increasing, the relative survival rate of kidney cancer has been dramatically i
Data Loading...
