The impact of COL1A1 and COL6A1 expression on hypospadias and penile curvature severity
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RESEARCH ARTICLE
Open Access
The impact of COL1A1 and COL6A1 expression on hypospadias and penile curvature severity Prahara Yuri1* , Gunadi2, Rahmadani Puji Lestari1, Firly Putri Fardilla1, Wiwit Ananda Wahyu Setyaningsih3, Nur Arfian3 and Ishandono Dachlan4
Abstract Background: Hypospadias, the most frequent congenital male external genitalia abnormality, is usually associated with curvature of the ventral penis, i.e. chordee. Abnormality of darto tissue has been suggested as the pathophysiology of chordees. Collagen is one of the most abundant fibrous proteins within the extracellular matrix. In this study, we determined the expression of collagen 1 (COL1A1) and COL6A1 in patients with hypospadias and associated them with the severity of penile curvature. Methods: We included 60 children
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