The outcome of kidney transplant from living donors with pelvi-ureteric junction dysfunction
- PDF / 903,652 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 19 Downloads / 154 Views
UROLOGY - ORIGINAL PAPER
The outcome of kidney transplant from living donors with pelvi‑ureteric junction dysfunction Miroslav Tisljar1,2 · Hatem Ali1 · Charlie Gledhill‑Flynn4 · Mila Garreus1 · Arvind Ponnusamy1,5 · Aimun Ahmed1,3,4 Received: 21 November 2019 / Accepted: 25 May 2020 © The Author(s) 2020
Abstract Purpose To assess the effect of receiving a kidney with PUJ dysfunction on the recipient renal graft function. Methodology 198 patients, who underwent renal transplantation from 1st January 2004 to 31st December 2014 in a single Center in the North West of England, were retrospectively reviewed using a computerized database. Split kidney function and the PUJ dysfunction for the donors were assessed using Tc-99 m MAG3 renogram. Each recipient with PUJ dysfunction was matched with a control recipient by age, gender, and number of days after transplantation. Both groups were followed up for 3.5 years post-transplantation. Results Of the 198 recipients included in the study, 19 recipients received kidneys from donors with PUJ dysfunction. Prevalence of PUJ dysfunction was 9.5% and it was more common in males than females. There was no difference between the case group and the control group in terms of age, gender, and follow-up time post-transplantation. There was also no difference between the case group and the control group in mean creatinine (130 µmol/l and 138 µmol/l respectively, p = 0.305) or the mean eGFR (48.6 ml/min and 47.5 ml/min respectively, p = 0.054) at 3.5 year post-kidney transplantation. Conclusion This study showed that PUJ dysfunction of renal allograft has a negligible effect on graft function over 3.5 years period post-transplantation. A prospective randomized trial is needed to test these findings. In the presence of widened gap between demand and supply in renal transplantation, PUJ dysfunction in potential donors should not preclude them from donation. Keywords Kidney transplant · Living donors · Pelvi-ureteric junction dysfunction · Kidney function
Introduction Kidney transplantation is the preferred option for patients with end-stage renal disease. It provides better quality of life and better survival when compared to dialysis [1, 2]. * Aimun Ahmed [email protected] 1
Renal Department, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation TrustSharoe Green, Fulwood, Preston PR2 9HT, UK
2
Nephrology Department, University Hospital Dubrava, Zagreb, Croatia
3
Nephrology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4
Manchester Medical School, University of Manchester, Manchester, UK
5
Institute of Cardiovascular Science, University of Manchester, Manchester, UK
Patients with end-stage renal disease are with compelling comorbidities and it is vital for potential recipients to be properly evaluated to assess and manage these comorbidities and risk factors that can affect the outcome of renal transplant [3, 4]. However, there is a wide gap between number of patients with end-stage renal disease seeking kidney transpl
Data Loading...
