The Pangenome Diversity, Dynamics and Evolution of Genomes
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of
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e Pangenome Diversity, Dynamics and Evolution of Genomes
The Pangenome
Hervé Tettelin • Duccio Medini Editors
The Pangenome Diversity, Dynamics and Evolution of Genomes
Editors Hervé Tettelin Department of Microbiology and Immunology, Institute for Genome Sciences University of Maryland School of Medicine Baltimore, Maryland, USA
Duccio Medini GSK Vaccines R&D Siena, Italy
ISBN 978-3-030-38280-3 ISBN 978-3-030-38281-0 https://doi.org/10.1007/978-3-030-38281-0
(eBook)
This book is an open access publication. © The Editor(s) (if applicable) and The Author(s) 2020. Open Access This book is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence and indicate if changes were made. The images or other third party material in this book are included in the book’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the book’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Serendipitous discoveries are fascinating events of science inducing, at times, paradigm shifts that give rise to new disciplines tout-court. This is what happened with pangenomics: a novel discipline at the intersection of biology, computer science and applied mathematics, whose discovery, development to state of the art and future perspectives are tentatively collected in this book for the first time, 15 years after its inception. In simple terms, the pangenome concept is the realization that the genetic repertoire of a biological species, i.e. the pool of genetic material present across the organisms of the species, always exceeds each of the individual genomes and can be, in several cases, “unbounded”: an open pangenom
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