Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature
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CASE REPORT
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Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature Merieme Ghaouti1,2*, Laurence Roquet1, Maximilien Baron1, Christian Pfister1 and Jean-Christophe Sabourin1
Abstract Thyroid-like follicular carcinoma of the kidney is an extremely rare histological variant of renal cell carcinoma. It was described only recently and is not included in the World Health Organization classification of renal tumors. This tumor characteristically shows similar histology to thyroid follicular carcinoma but lacks typical thyroid markers. Herein, we report a new case of thyroid-like follicular carcinoma of the kidney diagnosed in a partial nephrectomy specimen in a 68-year-old-woman. We present typical histological and immunohistochemical findings, discuss differential diagnosis and provide a review of the literature. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/13000_2014_186 Keywords: Thyroid-like follicular carcinoma of the kidney, Renal cell carcinoma, WHO classification, Metastatic follicular carcinoma of the thyroid
Background The World Health Organization (WHO) classification of tumors [1] introduced several new distinctive entities of renal cell carcinoma (RCC) in 2004, such as RCC associated with neuroblastoma, Xp11 translocation RCC and mucinous tubular and spindle cell carcinoma. However, since then a potentially new histological entity of renal tumor has emerged: thyroid-like follicular carcinoma of the kidney (TLFCK). This new entity has not yet been integrated into the new WHO classification and is supported by scattered clinical data. TLFCK is an extremely rare tumor with low malignant potential and exhibits morphologic features that strikingly resemble primary follicular carcinoma of the thyroid gland, but TLFCK is characteristically negative for thyroid immunohistochemical markers. The first case of TLFCK was reported in 2004 [2] and since then, to our knowledge, an additional 10 cases have been reported in the literature. We report a further case of this rare histological entity, discuss the clinical, histological and immunohistochemical findings and provide an update on the review of the literature. * Correspondence: [email protected] 1 Department of Cytopathology, Charles-Nicole Hospital, Rouen University Hospital, Rouen, France 2 Department of Urology and Andrology, Charles-Nicole Hospital, Rouen University Hospital, Rouen, France
Case presentation Case report
A 68-year-old white European presented to her urologist with a long history of relapsing urinary infection, with no hematuria. Except for a uterine prolapse cure 10 years previously, no relevant medical or family history was noted. Physical examination of the thyroid, abdomen and pelvis was normal. Biological data, including thyroid function tests, were within the normal ranges. A computed tomography scan showed a partially cystic enhancing lesion, measuring 11 mm in diameter, arising from the right kidney (Figure 1).
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