Topiramate
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Nonepileptic seizures: 2 case reports Two women with epilepsy developed nonepileptic seizures after topiramate was added to their existing antiepileptic therapy [dosage information incomplete or missing; routes and duration of treatments to reaction onsets not stated]. The 34-year-old woman started receiving topiramate in addition to her existing therapy with carbamazepine and valproate [salt not stated] for treatment-refractory complex partial seizures. At a topiramate dosage of 200mg, she developed longer-lasting seizures with new onset of symptoms such as eyelid myoclonus and incongruous verbalisation. At a topiramate dosage of 300mg, she developed multiday [sic] 2–4-minute episodes characterised by drop of the head, and weak and slow speech; her consciousness was preserved, and she was able to give correct verbal responses. An EEG recorded four episodes over the space of 2 hours without ictal discharge or interictal EEG variations. Topiramate was discontinued, and her symptoms resolved. The 22-year-old woman had a history of refractory seizures characterised by left arm dystonia with short episodes of disturbed consciousness, lasting for a few seconds. After topiramate was added to her existing therapy, she developed new seizure symptoms. After the usual dystonic seizure onset, she exhibited intermittent and repetitive vocalisation akin to clucking of a hen, followed by rhythmic movements of the trunk and singing; symptoms persisted for about 2 minutes and accompanied her usual icteric presentation. Topiramate was discontinued, and her nonepileptic seizures resolved. Author comment: "Two female patients affected by refractory partial epilepsy experienced nonepileptic seizures of possible psychogenic origin, while receiving a standard dosage of topiramate in add-on." Benna P, et al. Nonepileptic Seizures Induced by Pharmacological Overtreatment in Patients with Refractory Epilepsy. 29th International Epilepsy Congress : abstr. p380, 28 Aug 2011. Available from: URL: http://www.epilepsyrome2011.org 803060749 [abstract] - Italy
0114-9954/10/1371-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 1 Oct 2011 No. 1371
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