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Deep vein thrombosis and pulmonary embolism: 6 case reports In a retrospective chart review study of 107 patients received trauma care from January 2014 to June 2016, 6 patients (5 men and 1 woman) aged 25–63 years were described, who developed deep vein thrombosis following treatment with tranexamic acid. Additionally, one patient also developed pulmonary embolism following treatment with tranexamic acid [time to reaction onset and outcome not stated]. All patients, who had experienced a trauma event received IV tranexamic acid in a total dose of 1000–18286mg as a measure of trauma care. Additionally, they received fresh frozen plasma, packed red blood cells and platelets. At the time of admission, the patients had injury severity score of 17–43 with an INR of 1.07–1.39. The patients received tranexamic acid 47–130 minutes following traumatic event. Four patients underwent surgery within 24h of traumatic event and 5 patients underwent sequential compressions. Following the tranexamic acid therapy, all patients developed deep vein thrombosis (one at distal and one at right upper extremity). In addition to this, one patient also developed pulmonary embolism. Due to thrombosis/embolism, the patients required extended hospital stays. Tencza E, et al. Effect of tranexamic acid administration time on blood product use in urban trauma patients. American Journal of Health-System Pharmacy 77 (Suppl. 2): 803496970 S46-S53, 19 May 2020. Available from: URL: http://doi.org/10.1093/ajhp/zxaa074

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Reactions 22 Aug 2020 No. 1818