Treatment of Rhabdomyosarcoma
Soft tissue sarcoma comprises 7.4% of childhood soft tissue malignancies with rhabdomyosarcoma (RMS) being the most common soft tissue sarcoma in children. RMS can arise in virtually any site in the body. Presenting symptoms depend on the site of origin o
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Carola A. S. Arndt Editor
Sarcomas of Bone and Soft Tissues in Children and Adolescents
Pediatric Oncology Series Editors Gregory H. Reaman Center for Drug Evaluation and Research U.S. Food and Drug Administration Center for Drug Evaluation and Research Silver Spring, MD, USA Franklin O. Smith Medpace CINCINNATI, OH, USA
More information about this series at http://www.springer.com/series/5421
Carola A. S. Arndt Editor
Sarcomas of Bone and Soft Tissues in Children and Adolescents
Editor Carola A. S. Arndt Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester, MN USA
ISSN 1613-5318 ISSN 2191-0812 (electronic) Pediatric Oncology ISBN 978-3-030-51158-6 ISBN 978-3-030-51160-9 (eBook) https://doi.org/10.1007/978-3-030-51160-9 © Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
1 Epidemiology of Bone and Soft Tissue Sarcomas ������������������������ 1 Philip J. Lupo, Logan G. Spector, Schuyler O’Brien, Joshua D. Schiffman, and Simone Hettmer 2 Sarcoma Pathology and Biology ���������������������������������������������������� 17 Marielle Yohe, Javed Khan, and Erin Rudzinski 3 Staging and Imaging of Sarcoma���������������������������������������������������� 37 Carola A. S. Arndt and Andrea Ferrari 4 Multi-institutional Trials for Patients with Rhabdomyosarcoma: Lessons from North American Studies from 1967 Through 1997���������������������� 47 R. Beverly Raney, Carola A. S. Arndt, and Harold M. Maurer 5 Treatment of Rhabdomyosarcoma ������������������������������������������������ 53 Carola A. S. Arndt, Ewa Koscielniak, and Gianni Bisogno 6 Current Approaches to Therapy: Soft Tissue Sarcomas Other t
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