TRIM/RBCC Proteins

The genomic ‘golden age’ has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than fu

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Germana Meroni Editor

TRIM/RBCC Proteins

TRIM/RBCC Proteins

ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University ofNew York at Buffalo IRUN R. COHEN, The Weizmann Institute ofScience ABEL LAJTHA, N S. Kline Institute for Psy chiatric Research JOI-IN D. LAMBRIS, University ofPennsylvania RODOLFO PAOLETTI, University ofMilan Recent Vol umes in this Series Volume 761 OOCYTE BIOLOGYAND FERTILITY PRESERVATION Sam Kim Vol ume 762 HIV INTERACTIONS WITH DENDRITIC CELLS: INFECTION AND IMMUNITY Li Wu and Olivier Schwartz Vol ume 763 BIOLOGYAND REGULATION OF BLOOD-TISSUE BARRIERS C. Yan Cheng Volume 764 HOT TOPICS IN INFECTION AND IMMUNITY IX Andrew J. Pollard Volume 765 OXYGEN TRANSPORTTO TISSUE XXXIV Palm Welch and Ilarrison Bruley Vol ume 766 DIGENETIC TREMATODES Rafael Toledo and Bernard Fried Volume 767 DNA HELICASES AND DNA MOTOR PROTEINS Maria Spies Volume 768 TEN YEARS OF PROGRESS IN GW/P BODY RESEARCH Edward K.L. Chan and Marvin J. Fritzler Vol ume 769 TANDEM REPEAT POLYMORPHISMS: GENETIC PLASTICITY, NEURAL DIVERSITY AND DISEASE Anthony J. Hannan Volume 770 TRIM/RBCC PROTEINS Gerrnana Meroni A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

TRIM/RBCC Proteins Edited by Germana Meroni, PhD

Cluster in Biomedicine, CBM Sic.rl. , AREA Science Park, Trieste, Italy

Springer Science+Business Media, LLC Landes Bioscience

Springer Science+Business Media, LLC Landes Bioscience Copyright ©2012 Landes Bioscience and Springer Science+Business Media, LLC All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system; for exclusive use by the Purchaser ofthe work.

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ISBN 978-1-4614-5397-0 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect