Tumor Necrosis Factor
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T Cell ▶T Lymphocyte
T-Ag Definition T-Ag stands for the large tumor antigen (T-Ag) of the simian virus 40. ▶DNA-based Vaccination
T Lymphocyte Definition T lymphocyte (T cell) is a type of immune cell specialized for the production of surface receptors that recognize complexes of peptides that are associated with the products of major histocompatibility complex genes. T cells are divided into subpopulations: T helperinducer cells; T Supressor cells and cytotoxic T lynphocytes. ▶Autoimmune Disease ▶Autoimmunity
Tachycardia
Tagging / Tag Definition Tagging is a biochemical/genetic method of adding a functional group (tag) to a protein that will be recognized by a labeling reagent. ▶Two-dimensional Crystallization of Membrane Proteins ▶Electron Tomography
TAK1
Definition The term tachycardia characterizes an enhanced frequency of pulse of the heart. ▶Acute Intermittent Porphyria
Definition TAK1 denotes ▶TGFβ-activated kinase 1, which is a member of the ▶MAPK family and involved in TGF, IL–1/18, ▶LPS, Mac–1 and other signaling pathways. ▶Interleukins and Their Receptors, a Role in Regulating Hematopoietic Stem Cells
TAFs Definition The TAFs (TATA-binding protein (TBP) associated factors) are protein subunits of transscription factor complexes that include TBP. These proteins are specific for either RNA Polymerase I, II or III transcription. ▶Core Promoters
Talin Definition Talin refers to a 250 kDa protein that links many β integrin subunits to actin filaments. Talin binding to β
1840
TAMs
integrins may be a final common step in integrin activation. ▶Focal Adhesions ▶Integrin Signalling
Tangier Disease G ERD S CHMITZ , WOLFGANG E. K AMINSKI Institute for Clinical Chemistry and Laboratory Medicine, University Regensburg, Regensburg, Germany [email protected] [email protected]
TAMs Definition ▶Thymidine Analog Mutations
Tandem Mass Spectrometry Definition The term tandem mass spectrometry is also called ▶MS/MS analysis. It utilizes two mass spectrometers in a series connected by a chamber known as a collision cell. The sample to be examined is essentially sorted and weighed in the first mass spectrometer, followed by collisional fragmentation induced by an inert gas, and fragment mass analysis in the second mass spectrometer. By using this method, compounds of a complex mixture can be identified. MS/MS can also be applied for identification of structures of organic molecules and for sequencing of proteins. ▶Mass Spectrometry ▶Mass Spectrometry: ESI ▶Mass Spectrometry: Quantitation ▶MS/MS ▶SNP Detection and Mass Spectrometry
Tandem Repeats Definition Tandem repeats describe DNA units that are arranged in the head-to-tail manner. ▶Repetitive DNA
Familial HDL-deficiency syndromes such as Tangier disease (TD) are rare autosomal recessive disorders of lipid metabolism caused by mutations in the ▶ATPbinding cassette transporter ABCA1 (5). These syndromes are characterized by the almost complete absence of plasma ▶high-density lipoproteins (HDL) and variable degree
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