Twenty-four-hour real-time continuous monitoring of acute focal cerebral ischemia in rabbits based on magnetic inductive
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RESEARCH
BioMedical Engineering OnLine Open Access
Twenty‑four‑hour real‑time continuous monitoring of acute focal cerebral ischemia in rabbits based on magnetic inductive phase shift Shuang‑Lin Zhao1, Gui Jin1, Ze‑Lin Bai1, Jing‑Bo Chen1, Meng‑Wei Li2, Gen Li3, Wei Zhuang1, Yue‑Ning Liu1 and Ming‑Xin Qin1*
*Correspondence: [email protected] 1 College of Biomedical Engineering, Army Medical University, Chongqing 400038, China Full list of author information is available at the end of the article
Abstract Background: As a serious clinical disease, ischemic stroke is usually detected through magnetic resonance imaging and computed tomography. In this study, a noninvasive, non-contact, real-time continuous monitoring system was constructed on the basis of magnetic induction phase shift (MIPS) technology. The “thrombin induction method”, which conformed to the clinical pathological development process of ischemic stroke, was used to construct an acute focal cerebral ischemia model of rabbits. In the MIPS measurement, a “symmetric cancellation-type” magnetic induction sensor was used to improve the sensitivity and antijamming capability of phase detection. Methods: A 24-h MIPS monitoring experiment was carried out on 15 rabbits (10 in the experimental group and five in the control group). Brain tissues were taken from seven rabbits for the 2% triphenyl tetrazolium chloride staining and verification of the animal model. Results: The nonparametric independent-sample Wilcoxon rank sum test showed sig‑ nificant differences (p
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