Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas
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RESEARCH
Open Access
Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas Xianping Meng1†, Hongyan Lu2†, Xia Jiang2, Bin Huang2, Song Wu2, Guiping Yu2*
and Hongbao Cao3,4*
From 11th International Young Scientists School “Systems Biology and Bioinformatics” – SBB-2019 Novosibirsk, Russia. 24-28 June 2019
Abstract Background: Previous studies indicated a strong association between hyperkalemia and lung squamous cell carcinomas (LSCC). However, the underlying mechanism is not fully understood so far. Methods: Literature-based data mining was conducted to identify genes, molecule, and cell processes linked to both hyperkalemia and LSCC. Pathway analysis was performed to explore the interactive network, common-target network, and common-regulator network for both disorders. Then, a mega-analysis using 11 independent LSCC RNA expression datasets (358 LSCCs and 278 healthy controls) was performed to test the hypothesis that genes influencing hyperkalemia may also play roles in LSCC. Results: There was a significant overlap between the genes implicated with both diseases (20 genes, p-value = 4.98e15), which counts for 16% of all hyperkalemia genes (125 genes). Network analysis identified 12 molecules as common targets for hyperkalemia and LSCC, and 19 molecules as common regulators. Moreover, 19 molecules were identified within an interactive network, through which hyperkalemia and LSCC could exert influence on each other. In addition, meta-analysis identified one hyperkalemia promoter, SPP1, as a novel contributor for LSCC (LFC = 2.64; p-value = 2.81e6). MLR analysis suggests geographical region as an influential factor for the expression levels of SPP1 in LSCC patients (p value = 0.036, 0.054). Conclusion: Our results showed that there was a common molecular basis for the pathology of both hyperkalemia and LSCC, and that genes promoting hyperkalemia might also play roles in the development of LSCC. However, this study did not suggest hypercalcemia as a casual factor for LSCC. Keywords: Hyperkalemia, Lung squamous cell carcinomas, Mega-analysis, Pathway analysis, Multiple linear regression analysis
* Correspondence: [email protected]; [email protected] † Xiangping Meng and Hongyan Lu contributed equally to this work. 2 Department of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin 214400, Jiangsu, China 3 Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third p
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