Various drugs
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Hypersensitivity: 4 case reports In a retrospective study, four patients experienced hypersensitivity to multiple drugs [routes, indications, durations of treatment to reactions onset and outcomes not stated]. A 76-year-old woman developed a maculopapular rash on two occasions, as well as swelling of her arm due to ibuprofen and pseudoephedrine, domperidone or influenza virus vaccination. Skin prick testing was positive for domperidone. Patch testing was positive for pseudoephedrine, and intradermal testing produced a delayed reaction to influenza vaccines. A 53-year-old patient [sex not stated] had several episodes of swelling of the face with rifampicin, isoniazid and various macrolides [specific drugs not stated]. Intradermal testing with rifampicin and erythromycin were positive. A 77-year-old man had a maculopapular rash with ampicillin, as well as angioedema with tixocortol. Patch tests were positive for penicillins and corticosteroids. A 59-year-old woman experienced anaphylactic shock following an injection of radiocontrast media (RCM) [specific drug not stated]. Skin testing was positive for all of the tested RCM. She also developed angioedema with a penicillin [specific drug not stated] and urticaria with cotrimoxazole. A provocation test was positive with cefixime [Oroken]. Intradermal testing with cotrimoxazole caused itching and laryngeal discomfort. Author comment: "[Multiple drug hypersensitivity] has to be distinguished from co-sensitization in which the immunological disturbances induced by a first [cutaneous adverse drug reaction] by a "danger signal" facilitating the sensitization to other drugs." Studer M, et al. Does the multiple drug hypersensitivity exist?. European Annals of 803078435 Allergy and Clinical Immunology 42: 66, No. 2, 2010 - France
0114-9954/10/1424-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 20 Oct 2012 No. 1424
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