Verapamil overdose
- PDF / 130,685 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 11 Downloads / 149 Views
1
OS
Bowel necrosis: case report A 41-year-old woman developed delayed bowel necrosis after administering an intentional overdose of verapamil [Calan-SR]. The woman presented 2 hours after ingesting 30 × verapamil 240mg tablets. Activated charcoal and calcium gluconate were initiated; she was moved to the ICU. Normal vital signs were noted until 14 hours post-ingestion. The first sign of toxicity was bradycardia with a HR in the 40s; hypotension ensued followed by complete heart block and obtundation. She was intubated; hyperinsulin-euglyemia therapy, transvenous pacer implantation, haemodialysis, and lipid emulsion therapy, for 48 hours, were necessitated. Haemodynamic recovery was noted on day 8; she remained intubated. On day 9, fever with black stools ensued; abdominal CT performed on day 14 revealed colonic pneumatosis. Necrosis of the entire colon was observed during laparotomy; total colectomy was performed. The woman subsequently recovered, and 2 months after presentation, she was discharged to a rehabilitation centre. Author comment: "We present a case of delayed toxicity and bowel necrosis requiring total colectomy following a verapamil overdose." French LK, et al. Delayed bowel necrosis following overdose of sustained-release verapamil. Clinical Toxicology 50: 362 abstr. 337, No. 4, Apr 2012. Available 803095419 from: URL: http://dx.doi.org/10.3109/15563650.2012.669957 - USA
0114-9954/13/1477-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Reactions 9 Nov 2013 No. 1477
Data Loading...
