Warning Against the Use of Anti-Inflammatory Medicines to Cure COVID-19: Building Castles in the Air
- PDF / 210,297 Bytes
- 3 Pages / 595.276 x 790.866 pts Page_size
- 101 Downloads / 157 Views
EDITORIAL
Warning Against the Use of Anti-Inflammatory Medicines to Cure COVID-19: Building Castles in the Air Giustino Varrassi
Received: March 23, 2020 The Author(s) 2020
Keywords: Anti-inflammatory COVID-19; NSAIDs
medicines;
Key Summary Points COVID-19 is developing rapidly and invading the whole world in a real pandemic. There is much discussion, appropriate or less appropriate, of this hot topic. Recent declarations have focused attention on the risk of interactions between NSAIDs and COVID-19. There are also theories on the potential interactions between the use of ACE inhibitors, the use of ibuprofen and the increased risk of infection. At the moment, there are no data in the literature showing that this would be the case.
Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.12029571. G. Varrassi (&) Paolo Procacci Foundation, via Tacito 7, 00193 Rome, Italy e-mail: [email protected]
Pain patients may be reassured by their physicians on the safety of using ACE inhibitors and NSAIDs (especially ibuprofen), because there is nothing to show the potential for an increased risk of viral infection, and especially of COVID-19. A recent article in Le Figaro has focused attention on the use of anti-inflammatory medicines because they could be responsible for an increased incidence of infections due to COVID-19 [1]. This article reports and emphasizes the opinion of politicians expressed via social media suggesting the use of one medicine instead of others, but not referencing opinions based on scientific data. A recent article focused its attention on the supposed relationship between chronic pathologies (hypertension and diabetes mellitus) and COVID-19 infection and their pharmacological treatment [2]. The initial assumption is based on two recent papers reporting the clinical experience in China, during the dramatic epidemic now becoming a pandemic [3, 4]. Both articles suggest that patients affected by COVID-19 frequently had concomitant chronic pathologies, especially hypertension and diabetes mellitus, pathologies that might be treated with angiotensin-converting-enzyme (ACE) inhibitors. Fang et al. [2]
Adv Ther
based their intriguing theory, of an increased risk of COVID-19 infection on patients treated with ACE inhibitors, on the relationship between the ACE system, which can be influenced by anti-inflammatory medicines, and the lung epithelial cells. Following this theory, their conclusion was the most obvious: ‘‘…patients …treated with ACE2-increasing drugs are at higher risk for severe COVID-19 infection…’’. None of the quoted articles reporting the clinical experience in China has assessed the previous pharmacological therapy of the patients infected by COVID-19 [3, 4]. In the last part of this recent article, the authors suggest that, based on a search on PubMed made on February 28, 2020, there are no reports on the potential influence of calcium channel blockers on ACE2 activity [2]. Therefore, these drugs could be used as an
Data Loading...
