Zoledronic Acid Attenuates Early Bone Loss at Forearm in Patients with Acute Spinal Cord Injury
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ORIGINAL ARTICLE
Zoledronic Acid Attenuates Early Bone Loss at Forearm in Patients with Acute Spinal Cord Injury Sunil Goenka1 · Satyaranjan Sethi1 Received: 6 January 2020 / Accepted: 25 May 2020 / Published online: 2 June 2020 © Indian Orthopaedics Association 2020
Abstract Study design Randomized controlled trial. Objectives To study the magnitude of bone loss at forearm in persons with acute spinal cord injury (SCI) & the effect of early administration of Zoledronic acid on its’ prevention. Settings Sawai Man Singh Medical College, Jaipur, India. Methods Sixty patients with acute SCI were randomized either to receive standard medical and nursing care or Zoledronic acid infusion in combination with standard medical and nursing care. Areal bone mineral density (aBMD) was measured at the forearm (radius + ulna) once patients were medically stable using Dual Energy X-Ray Absorptiometry (DXA) at baseline and at 3, 6 and 12 months. Results Significant differences in aBMD was found between the control & Zoledronic acid group at 1/3 forearm (− 0.064; 95% CI − 0.092 to − 0.036, p = 0.001), mid forearm (− 0.059; 95% CI − 0.084 to − 0.034, p = 0.001), UD forearm (− 0.048; 95% CI − 0.097 to 0.001, p = 0.016) and total forearm (− 0.048; 95% CI − 0.088 to − 0.008, p = 0.021) at 1 year in the paraplegic patients with SCI. Similar significant difference was also observed at 1/3 forearm (− 0.046; 95% CI − 0.073 to − 0.019, p = 0.002), mid forearm (− 0.063; 95% CI − 0.088 to − 0.037, p
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