Quality of interventional animal experiments in Chinese journals: compliance with ARRIVE guidelines
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RESEARCH ARTICLE
Open Access
Quality of interventional animal experiments in Chinese journals: compliance with ARRIVE guidelines Bing Zhao1†, Yanbiao Jiang2, Ting Zhang1, Zhizhong Shang2, Weiyi Zhang3, Kaiyan Hu4†, Fei Chen4, Fan Mei4, Qianqian Gao4, Li Zhao4, Joey S. W. Kwong5* and Bin Ma1*
Abstract Background: In view of the inadequacy and incompleteness of currently-reported animal experiments and their overall poor quality, we retrospectively evaluated the reporting quality of animal experiments published in Chinese journals adhering to the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines. Results: The databases CNKI, WanFang, VIP, and CBM were searched from inception until July 2018. Two appropriatelytrained reviewers screened and extracted articles independently. The ARRIVE guidelines were used to assess the quality of the published reports of animal experiments. The compliance rate of every item was analyzed relative to their date of publication. A total of 4342 studies were included, of which 73.0% had been cited ≤5 times. Only 29.0% (1261/4342) were published in journals listed in the Chinese Science Citation Database. The results indicate that the compliance rate of approximately half of the sub-items (51.3%, 20/39) was less than 50%, of which 65.0% (13/20) was even less than 10%. Conclusions: The reporting quality of animal experiments in Chinese journals is not at a high level. Following publication of the ARRIVE guidelines in 2010, the compliance rate of the majority of its requirements has improved to some extent. However, less attention has been paid to the ethics and welfare of experimental animals, and a number of specific items in the Methods, Results, and Discussion sections continue to not be reported in sufficient detail. Therefore, it is necessary to popularize the ARRIVE guidelines, advocate researchers to adhere to them in the future, and in particular promote the use of the guidelines in specialized journals in order that the design, implementation, and reporting of animal experiments is promoted, to ultimately improve their quality. Keywords: Animal experiments, ARRIVE, Reporting quality
Background Animal experimentation in scientific research is required for the acquisition of new knowledge of mechanisms in biology and medicine, or to answer specific scientific * Correspondence: [email protected]; [email protected] † Bing Zhao and Kaiyan Hu contributed equally to this work. 5 School of Public Health and Primary Medical Care, Jockey Club, Chinese University of Hong Kong, Hong Kong 999077, China 1 Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, No.199, Donggang West Road, Lanzhou City 730000, Gansu Province, China Full list of author information is available at the end of the article
questions [1], and so represents a basic tenet of biomedical research. Animal experiments are also an important aspect of preclinical research. As a bridge between basic research and clinical trials, the quality of animal experiments affects t
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