Quality of Life Evaluation Abstracts
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Drug Infonnnfion J o u m l , Vol. 31, pp. 1407-1439. 1997 Printed in the USA. All rights reserved.
QUALITY OF LIFE EVALUATION ABSTRACTS ABSTRACTS The following abstracts are from the “Fourth Annual DIA Symposium on Contributed Papers on Quality of Life Evaluation,” held in Charleston, South Carolina, May 12-13, 1997.
Quality of Life Evaluation of Acne Patients Participating in a Clinical Wal of Anti-Acne Products. Roger T. Anderson, PhD, Bowman Gray Medical centec Winston-Salem, North Carolina; Wd Rukmini Rajagopalan, Dr PH, MBA, RN, Glaxo Wellcome Research Triangle Park. North Carolina
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x373. r Spanish patients with mild to moderate hyperten- 3. Testa MA et al. Quality of life and antihypertensive therapy in men. A comparison of captopril and enalasion were randomly assigned to receive either pril. N Eng J Med. 1993;328:907-913. nifedipine GITS (30 mg) or amlodipine (5 mg), , double-blind. METHODS-Patients were enrolled for three weeks of placebo run-in, three weeks of titration, and 21 weeks of maintenance therapy. QOL as- Quality of Life Evaluations for Total Knee Arsessments occurred at screening, baseline ran- throplasty Procedures. Marcos Velez-Duran, domization, end of titration (week lo), week 22, Smith & Nephew Orthopaedics; and Debbie Robertson, Department of Orthopaedic Surgery, Uniand week 27. QOL ASSESSMENT-A self-administered versity Hospital QOL battery was translated using standard techThe usefulness of generic and disease-specific niques. The battery produced Overall Quality of Life, Psychological Well-Being, Psychological health status instruments for the evaluation of imDistress, General Perceived Health and several provements in quality of life for patients undergosubscales. Patients reported the impact of side ing knee arthroplasty continues to be debated. Based on a database designed to capture voluntary effects and symptoms. R E S U L T S 4 n e hundred and twenty two data collection by orthopaedic surgeons on their nifedipine GITS and 130 amlodipine patients medical practice, the effect of total knee arcompleted 27 weeks. No clinically important throplasty (TKA) on patients' quality of life was baseline differences were found, nor significant evaluated. A total of 56 primary TKA patients differences in blood pressure changes. Significant with a primary diagnosis of osteoarthritis were treatment-related side-effects were used as a co- analyzed using the SF-36 Health Status Questionvariate in the analyses. Nifedipine GITS patients naire and the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index. The reimproved in Overall Quality of Life (p = O M ) , Mental and Emotional Health (p = 0.03). Psycho- sults of the physician assessments of pain and logical Distress (p = 0.02), Anxiety (p = 0.01), function based on the Knee Society Scoring Sysand Depression (p = .05).Amlodipine patients im- tem were also analyzed. The improvement in asproved in Mental and Emotional Health ( p = sessments at two years postoperatively from pre0.04), Psychological Well-Being (p = 0.04), and opera
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