Quantification of 4D left ventricular blood flow organization in normal and failing hearts
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BioMed Central
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Quantification of 4D left ventricular blood flow organization in normal and failing hearts Carl Johan Carlhäll*1, Jonatan Eriksson1,2, Petter Dyverfeldt1,2, Tino Ebbers1,2, Jan Engvall1,2 and Ann F Bolger3 Address: 1Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping, Sweden and 3University of California San Francisco, San Francisco, CA, USA * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P70
doi:10.1186/1532-429X-12-S1-P70
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P70 © 2010 Carlhäll et al; licensee BioMed Central Ltd.
Objective To measure the volume and distribution of separate flow components in normal and dysfunctional left ventricles (LV).
diac cycle. The IVR volume was used to determine if and where the traces left the LV. This information was used to automatically separate the pathlines into four different LV flow components [3,4](Table 1, Figure 1).
Background The forces created by blood flow dictate a continuous remodeling of cardiac structures. In the normal heart this mechanism interactively creates an optimal geometry for efficient flow [1]. In various cardiac disorders such as LV dysfunction, however, the normal flow organization may be altered, leading to negative remodelling. The description and quantification of the true 4D (3D+time) blood flow organization in dysfunctional LVs remains incomplete.
Method Seven dilated cardiomyopathy (DCM) patients (4 female, aged 52 ± 14 years [mean ± SD]) and six healthy subjects (3 female, aged 58 ± 4 years) were studied. Three-directional, 3-dimensional cine phase-contrast-MRI velocity data and morphological b-SSFP long- and short-axis images were acquired on a clinical 1.5 T MRI scanner (Philips Achieva). The LV endocardium was segmented (http://segment.heiberg.se, [2]) from the short-axis images at the times of isovolumetric contraction (IVC) and isovolumetric relaxation (IVR). Pathlines were emitted from the IVC LV blood volume and traced forward and backward in time until IVR, thus covering the entire car-
Figure Pathline diastole year old1in visualization female a healthy with58 dilated of year LV blood cardiomyopathy old female flow organization (left panel) (right and panel) at early a 61 Pathline visualization of LV blood flow organization at early diastole in a healthy 58 year old female (left panel) and a 61 year old female with dilated cardiomyopathy (right panel). Green, direct flow; yellow, retained inflow; blue, delayed ejection flow; and red, residual volume. LA, left atrium; and LV, left vemtricle.
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