Quantification of pleural effusion from single area measurements on CT
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ORIGINAL ARTICLE
Quantification of pleural effusion from single area measurements on CT Branislav Veljkovic & Sabine Franckenberg & Gary M. Hatch & Matthias Bucher & Nicole Schwendener & Garyfalia Ampanozi & Michael J. Thali & Thomas D. Ruder
Received: 4 January 2013 / Accepted: 3 March 2013 / Published online: 16 March 2013 # Am Soc Emergency Radiol 2013
Abstract The objective of this study was to determine if area measurements of pleural fluid on computed tomography (CT) reflect the actual pleural fluid volume (PEvol) as measured at autopsy, to establish a formula to estimate the volume of pleural effusion (PEest), and to test the accuracy and observer reliability of PEest.132 human cadavers, with pleural effusion were divided into phase 1 (n=32) and phase 2 (n=100). In phase 1, PEvol was compared to area measurements on axial (axA), sagittal (sagA), and coronal
B. Veljkovic Department of Internal Medicine, Kantonsspital Baselland, CH-4101 Bruderholz, Switzerland S. Franckenberg : M. Bucher : N. Schwendener : G. Ampanozi : M. J. Thali : T. D. Ruder Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Winterthurerstrasse 190/52, CH-8057 Zurich, Switzerland G. M. Hatch Radiology–Pathology Center for Forensic Imaging, Departments of Radiology and Pathology, University of New Mexico, MSC07 4040, 1101 Camino de Salud NE, Albuquerque, NM 87102, USA N. Schwendener Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, CH-3012 Bern, Switzerland T. D. Ruder (*) Department of Diagnostic, Pediatric, and Interventional Radiology, University Hospital Bern, CH-3010 Bern, Switzerland e-mail: [email protected] T. D. Ruder e-mail: [email protected]
(corA) CT images. Linear regression analysis was used to create a formula to calculate PEest. In phase 2, intra-class correlation (ICC) was used to assess inter-reader reliability and determine the agreement between PEest and PEvol. PEvol correlated to a higher degree to axA (rs mean= 0.738; p
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