Quantitative characterization of extraocular orbital lesions in children using diffusion-weighted imaging
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ORIGINAL ARTICLE
Quantitative characterization of extraocular orbital lesions in children using diffusion-weighted imaging Francisco R. Maldonado 1
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& Juan P. Princich & Lucia Micheletti & María S. Toronchik & José I. Erripa & Carlos Rugilo
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Received: 7 April 2020 / Revised: 16 July 2020 / Accepted: 10 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background Diffusion-weighted imaging (DWI) has been shown to be helpful in providing information about cellular density and also predicting the histological features of aggressive tumors. Several studies have evaluated this technique for orbital tumors. However, very few articles have focused exclusively on evaluating pediatric orbital masses and, within those, only a small number of patients were included in the study. Objective This study aimed to evaluate the use of DWI and apparent diffusion coefficient (ADC) values to differentiate between benign and malignant extraocular orbital lesions in children. Materials and methods This retrospective study included 73 patients under the age of 18 seen in our hospital between October 2016 and February 2019. The extraocular orbital lesions were evaluated clinically and radiologically using DWI. The diagnosis was confirmed by either histological examination (after biopsy or surgery) or based on clinical and radiologic evaluation. Results The malignant lesions were found to have increased diffusion restriction in comparison to the benign lesions. The ADC values of the malignant lesions were significantly lower (P
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