Quantitative fluorescence angiography detects dynamic changes in gastric perfusion
- PDF / 1,374,069 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 9 Downloads / 181 Views
and Other Interventional Techniques
Quantitative fluorescence angiography detects dynamic changes in gastric perfusion Jens Osterkamp1 · Rune Strandby1 · Nikolaj Nerup1 · Morten Svendsen2 · Lars Svendsen1 · Michael Achiam1 Received: 23 June 2020 / Accepted: 17 November 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Introduction The use of Indocyanine green (ICG) fluorescence angiography (ICG-FA) is an applied method to assess visceral perfusion during surgical procedures worldwide. Further development has entailed quantification of the fluorescence signal; however, whether quantified ICG-FA can detect intraoperative changes in perfusion after hemorrhage has not been investigated previously. In this study, we investigated whether a quantification method, developed and validated in our department (q-ICG), could detect changes in gastric perfusion induced by hemorrhage and resuscitation. Methods Ten pigs were included in the study. Specific regions of interest of the stomach were chosen, and three q-ICG measurements of gastric perfusion obtained: 20 min after completion of the laparoscopic setup (baseline), after reducing the circulating blood volume by 30%, and after reinfusion of the withdrawn blood volume. Hemodynamic variables were recorded, and blood samples were collected every 10 min during the procedure. Results The reduction in blood volume generated decreased gastric perfusion (q-ICG) from baseline (p = 0.023), and gastric perfusion subsequently increased (p
Data Loading...
